|
|
||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
E-mail contact: phssp@ nus.edu.sg
The annexin superfamily consists of 13 calcium or calcium and phospholipid binding proteins with a significant degree of biological and structural homology (40-60%). First described in the late 1970s and subsequently referred to as macrocortin, renocortin, lipomodulin, lipocortin-1, and more recently Annexin 1, this 37 kDa calcium and phospholipid binding protein is a strong inhibitor of glucocorticoid-induced eicosanoid synthesis and PLA2. Recent interest in the biological activity of this intriguing molecule has unraveled important functional attributes of Annexin 1 in a variety of inflammatory pathways, on cell proliferation machinery, in the regulation of cell death signaling, in phagocytic clearance of apoptosing cells, and most importantly in the process of carcinogenesis. Here we attempt to present a short review on these diverse biological activities of an interesting and important molecule, which could be a potential target for novel therapeutic intervention in a host of disease states.-- Lim, L. H. K., Pervaiz, S. Annexin 1: the new face of an old molecule.
This article has been cited by other articles:
![]() |
K. Chen, Y. Le, Y. Liu, W. Gong, G. Ying, J. Huang, T. Yoshimura, L. Tessarollo, and J. M. Wang Cutting Edge: A Critical Role for the G Protein-Coupled Receptor mFPR2 in Airway Inflammation and Immune Responses J. Immunol., April 1, 2010; 184(7): 3331 - 3335. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. C. Cote, J. R. Lavoie, F. Houle, A. Poirier, S. Rousseau, and J. Huot Regulation of Vascular Endothelial Growth Factor-induced Endothelial Cell Migration by LIM Kinase 1-mediated Phosphorylation of Annexin 1 J. Biol. Chem., March 12, 2010; 285(11): 8013 - 8021. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Grzendowski, M. Wolter, M. J. Riemenschneider, C. B. Knobbe, U. Schlegel, H. E. Meyer, G. Reifenberger, and K. Stuhler Differential proteome analysis of human gliomas stratified for loss of heterozygosity on chromosomal arms 1p and 19q Neuro Oncology, March 1, 2010; 12(3): 243 - 256. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Yi and J. E. Schnitzer Impaired tumor growth, metastasis, angiogenesis and wound healing in annexin A1-null mice PNAS, October 20, 2009; 106(42): 17886 - 17891. [Abstract] [Full Text] [PDF] |
||||
![]() |
F. Li and T. E. Curry Jr. Regulation and Function of Tissue Inhibitor of Metalloproteinase (TIMP) 1 and TIMP3 in Periovulatory Rat Granulosa Cells Endocrinology, August 1, 2009; 150(8): 3903 - 3912. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Inokuchi, A. Lau, D. R. Tyson, and D. K. Ornstein Loss of annexin A1 disrupts normal prostate glandular structure by inducing autocrine IL-6 signaling Carcinogenesis, July 1, 2009; 30(7): 1082 - 1088. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Ametzazurra, R. Matorras, J.A. Garcia-Velasco, B. Prieto, L. Simon, A. Martinez, and D. Nagore Endometrial fluid is a specific and non-invasive biological sample for protein biomarker identification in endometriosis Hum. Reprod., April 1, 2009; 24(4): 954 - 965. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Santos, L. Gonzalez-Sanchez, M. Matabuena-deYzaguirre, M. Villa-Morales, P. Cozar, P. Lopez-Nieva, P. Fernandez-Navarro, M. Fresno, M. D. Diaz-Munoz, J.-L. Guenet, et al. A Role for Stroma-Derived Annexin A1 as Mediator in the Control of Genetic Susceptibility to T-Cell Lymphoblastic Malignancies through Prostaglandin E2 Secretion Cancer Res., March 15, 2009; 69(6): 2577 - 2587. [Abstract] [Full Text] [PDF] |
||||
![]() |
E. Z.-F. Ang, H. T. Nguyen, H.-L. Sim, T. C. Putti, and L. H.K. Lim Annexin-1 Regulates Growth Arrest Induced by High Levels of Estrogen in MCF-7 Breast Cancer Cells Mol. Cancer Res., February 1, 2009; 7(2): 266 - 274. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Yogi, G. E. Callera, R. Tostes, and R. M. Touyz Bradykinin regulates calpain and proinflammatory signaling through TRPM7-sensitive pathways in vascular smooth muscle cells Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2009; 296(2): R201 - R207. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Lee, J. Feng, K. B. Campbell, B. E. Scheffler, W. M. Garrett, S. Thibivilliers, G. Stacey, D. Q. Naiman, M. L. Tucker, M. A. Pastor-Corrales, et al. Quantitative Proteomic Analysis of Bean Plants Infected by a Virulent and Avirulent Obligate Rust Fungus Mol. Cell. Proteomics, January 1, 2009; 8(1): 19 - 31. [Abstract] [Full Text] [PDF] |
||||
![]() |
T. S. Gastardelo, A. S. Damazo, J. Dalli, R. J. Flower, M. Perretti, and S. M. Oliani Functional and Ultrastructural Analysis of Annexin A1 and Its Receptor in Extravasating Neutrophils during Acute Inflammation Am. J. Pathol., January 1, 2009; 174(1): 177 - 183. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Bertin, M. Samson, C. Pons, J.-M. Guigonis, A. Gavelli, P. Baque, N. Brossette, S. Pagnotta, J.-E. Ricci, and V. Pierrefite-Carle Comparative Proteomics Study Reveals That Bacterial CpG Motifs Induce Tumor Cell Autophagy in Vitro and in Vivo Mol. Cell. Proteomics, December 1, 2008; 7(12): 2311 - 2322. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. E. Tagoe, N. Marjanovic, J. Y. Park, E. S. Chan, A. M. Abeles, M. Attur, S. B. Abramson, and M. H. Pillinger Annexin-1 Mediates TNF-{alpha}-Stimulated Matrix Metalloproteinase Secretion from Rheumatoid Arthritis Synovial Fibroblasts J. Immunol., August 15, 2008; 181(4): 2813 - 2820. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Menegay, D. Lee, K. F. Tabbara, T. A. Cafaro, J. A. Urrets-Zavalia, H. M. Serra, and S. K. Bhattacharya Proteomic Analysis of Climatic Keratopathy Droplets Invest. Ophthalmol. Vis. Sci., July 1, 2008; 49(7): 2829 - 2837. [Abstract] [Full Text] [PDF] |
||||
![]() |
B. Sontia, A. C.I. Montezano, T. Paravicini, F. Tabet, and R. M. Touyz Downregulation of Renal TRPM7 and Increased Inflammation and Fibrosis in Aldosterone-Infused Mice: Effects of Magnesium Hypertension, April 1, 2008; 51(4): 915 - 921. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Sakaguchi, H. Murata, H. Sonegawa, Y. Sakaguchi, J.-i. Futami, M. Kitazoe, H. Yamada, and N.-h. Huh Truncation of Annexin A1 Is a Regulatory Lever for Linking Epidermal Growth Factor Signaling with Cytosolic Phospholipase A2 in Normal and Malignant Squamous Epithelial Cells J. Biol. Chem., December 7, 2007; 282(49): 35679 - 35686. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. P. Herbert, A. F. Odell, S. Ponnambalam, and J. H. Walker The Confluence-dependent Interaction of Cytosolic Phospholipase A2-{alpha} with Annexin A1 Regulates Endothelial Cell Prostaglandin E2 Generation J. Biol. Chem., November 23, 2007; 282(47): 34468 - 34478. [Abstract] [Full Text] [PDF] |
||||
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |