FASEB J.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (Rapid PDF)
Right arrow Supplement Data
Right arrow All Versions of this Article:
fj.06-7061comv1
21/2/393    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bloch, I.
Right arrow Articles by Shai, Y.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bloch, I.
Right arrow Articles by Shai, Y.
Related Collections
Right arrowRelated Articles
Published online before print December 21, 2006 as doi: 10.1096/fj.06-7061com.

T-Cell inactivation and immunosuppressive activity induced by HIV gp41 via novel interacting motif

Itai Bloch, Francisco J. Quintana, Doron Gerber, Tomer Cohen, Irun R. Cohen, and Yechiel Shai

E-mail contact: yechiel.shai@weizmann.ac.il

Fusion peptide (FP) of the HIV gp41 molecule inserts into the T cell membrane during virus-cell fusion. FP also blocks the TCR/CD3 interaction needed for antigen-triggered T cell activation. Here we used in vitro (fluorescence and immunoprecipitation), in vivo (T cell mediated autoimmune disease adjuvant arthritis), and in silico methods to identify the FP-TCR novel interaction motif: the {alpha}-helical transmembrane domain (TMD) of the TCR {alpha} chain, and the {beta}-sheet 5-13 region of the 16 N-terminal aa of FP (FP1-16). Deciphering the molecular mechanism of the immunosuppressive activity of FP provides a new potential target to overcome the immunosuppressant activity of HIV, and in addition a tool for down-regulating immune mediated inflammation.--Bloch, I., Quintana, F. J., Gerger, D., Cohen, T., Cohen, I. R., and Shai, Y. T-Cell inactivation and immunosuppressive activity induced by HIV gp41 via novel interacting motif.


Related Articles

Interaction between HIV gp41 fusion peptide and T cell receptor: putting the puzzle pieces back together
Alexander B. Sigalov
FASEB J 2007 21: 1633-1634. [Full Text] [PDF]

Response to "Interaction between HIV gp41 fusion peptide and T cell receptor: putting the puzzle pieces back together"
Francisco J. Quintana, Doron Gerber, Itai Bloch, Irun R. Cohen, and Yechiel Shai
FASEB J 2007 21: 1635. [Full Text] [PDF]



This article has been cited by other articles:


Home page
 FASEB J.Home page
A. B. Sigalov
Interaction between HIV gp41 fusion peptide and T cell receptor: putting the puzzle pieces back together
FASEB J, June 1, 2007; 21(8): 1633 - 1634.
[Full Text] [PDF]

Home page
 FASEB J.Home page
F. J. Quintana, D. Gerber, I. Bloch, I. R. Cohen, and Y. Shai
Response to "Interaction between HIV gp41 fusion peptide and T cell receptor: putting the puzzle pieces back together"
FASEB J, June 1, 2007; 21(8): 1635 - 1635.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Copyright © 2006 by The Federation of American Societies for Experimental Biology.