FASEB J.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (Rapid PDF)
Right arrow Supplemental Data
Right arrow All Versions of this Article:
fj.06-6638fjev1
20/14/2633    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Blázquez, C.
Right arrow Articles by Guzmán, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Blázquez, C.
Right arrow Articles by Guzmán, M.
Published online before print October 25, 2006 as doi: 10.1096/fj.06-6638fje.

Cannabinoid receptors as novel targets for the treatment of melanoma

Cristina Blázquez, Arkaitz Carracedo, Lucía Barrado, Pedro José Real, José Luis Fernández-Luna, Guillermo Velasco, Marcos Malumbres, and Manuel Guzmán

E-mail contact: mgp@bbm1.ucm.es

Melanoma causes the greatest number of skin cancer-related deaths worldwide. Despite intensive research, prevention and early detection are the only effective measures against melanoma, so new therapeutic strategies are necessary for the management of this devastating disease. Here, we evaluated the efficacy of cannabinoid receptor agonists, a new family of potential antitumoral compounds, at skin melanoma. Human melanomas and melanoma cell lines express CB1 and CB2 cannabinoid receptors. Activation of these receptors decreased growth, proliferation, angiogenesis and metastasis, and increased apoptosis, of melanomas in mice. Cannabinoid antimelanoma activity was independent of the immune status of the animal, could be achieved without overt psychoactive effects and was selective for melanoma cells vs. normal melanocytes. Cannabinoid antiproliferative action on melanoma cells was due, at least in part, to cell cycle arrest at the G1-S transition via inhibition of the prosurvival protein Akt and hypophosphorylation of the pRb retinoblastoma protein tumor suppressor. These findings may contribute to the design of new chemotherapeutic strategies for the management of melanoma.--Blázquez, C., Carracedo, A., Barrado, L., Real, P. J., Fernández-Luna, J. L., Velasco, G., Malumbres, M., and Guzmán, M. Cannabinoid receptors as novel targets for the treatment of melanoma.




This article has been cited by other articles:


Home page
 FASEB J.Home page
N. Dobrosi, B. I. Toth, G. Nagy, A. Dozsa, T. Geczy, L. Nagy, C. C. Zouboulis, R. Paus, L. Kovacs, and T. Biro
Endocannabinoids enhance lipid synthesis and apoptosis of human sebocytes via cannabinoid receptor-2-mediated signaling
FASEB J, October 1, 2008; 22(10): 3685 - 3695.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
D. Zheng, A. M. Bode, Q. Zhao, Y.-Y. Cho, F. Zhu, W.-Y. Ma, and Z. Dong
The Cannabinoid Receptors Are Required for Ultraviolet-Induced Inflammation and Skin Cancer Development
Cancer Res., May 15, 2008; 68(10): 3992 - 3998.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
C. Blazquez, M. Salazar, A. Carracedo, M. Lorente, A. Egia, L. Gonzalez-Feria, A. Haro, G. Velasco, and M. Guzman
Cannabinoids Inhibit Glioma Cell Invasion by Down-regulating Matrix Metalloproteinase-2 Expression
Cancer Res., March 15, 2008; 68(6): 1945 - 1952.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. Paradisi, N. Pasquariello, D. Barcaroli, and M. Maccarrone
Anandamide Regulates Keratinocyte Differentiation by Inducing DNA Methylation in a CB1 Receptor-dependent Manner
J. Biol. Chem., March 7, 2008; 283(10): 6005 - 6012.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
S. Sarfaraz, V. M. Adhami, D. N. Syed, F. Afaq, and H. Mukhtar
Cannabinoids for Cancer Treatment: Progress and Promise
Cancer Res., January 15, 2008; 68(2): 339 - 342.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
A. Telek, T. Biro, E. Bodo, B. I. Toth, I. Borbiro, G. Kunos, and R. Paus
Inhibition of human hair follicle growth by endo- and exocannabinoids
FASEB J, November 1, 2007; 21(13): 3534 - 3541.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Copyright © 2006 by The Federation of American Societies for Experimental Biology.