FASEB J.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (Rapid PDF)
Right arrow All Versions of this Article:
fj.06-5910fjev1
20/12/2153    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Morris, G. E.
Right arrow Articles by Sabroe, I.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Morris, G. E.
Right arrow Articles by Sabroe, I.
Published online before print August 25, 2006 as doi: 10.1096/fj.06-5910fje.

Cooperative molecular and cellular networks regulate Toll-like receptor-dependent inflammatory responses

Gavin E. Morris, Lisa C. Parker, Jon R. Ward, Elizabeth C. Jones, Moira K. B. Whyte, Christopher E. Brightling, Peter Bradding, Steven K. Dower, and Ian Sabroe

E-mail contact: i.sabroe@sheffield.ac.uk

Viral and bacterial pathogens cause inflammation via Toll-like receptor (TLR) signaling. We have shown that effective responses to LPS may depend on cooperative interactions between TLR-expressing leukocytes and TLR-negative tissue cells. The aim of this work was to determine the roles of such networks in response to agonists of TLRs associated with antiviral and autoimmune responses. The TLR3 agonist poly(I:C) activated epithelial cells, primary endothelial cells, and two types of primary human smooth muscle cells (airway [ASMC] and vascular) directly, while the TLR7/8 agonist R848 required the presence of leukocytes to activate ASMC. In keeping with these data, ASMC expressed TLR3 but not TLR7 or TLR8. Activation of ASMC by poly(I:C) induced a specific cytokine repertoire characterized by induction of CXCL10 generation and the potential to recruit mast cells. We subsequently explored the ability of TLR agonists to cooperate in the induction of inflammation. Dual stimulation with LPS and poly(I:C) caused enhanced cytokine generation from epithelial and smooth muscle cells when in the presence of leukocytes. Thus, inflammatory responses to pathogens are regulated by networks in which patterns of TLR expression and colocalization of tissue cells and leukocytes are critical.--Morris, G. E., Parker, L. C., Ward, J. R., Jones, E. C., Whyte, M. K. B., Brightling, C. E., Bradding, P., Dower, S. K., Sabroe, I. Cooperative molecular and cellular networks regulate Toll-like receptor-dependent inflammatory responses.




This article has been cited by other articles:


Home page
 J. Immunol.Home page
L. C. Parker, E. C. Prestwich, J. R. Ward, E. Smythe, A. Berry, M. Triantafilou, K. Triantafilou, and I. Sabroe
A Phosphatidylserine Species Inhibits a Range of TLR- but Not IL-1{beta}-Induced Inflammatory Responses by Disruption of Membrane Microdomains
J. Immunol., October 15, 2008; 181(8): 5606 - 5617.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
F. J. Roca, I. Mulero, A. Lopez-Munoz, M. P. Sepulcre, S. A. Renshaw, J. Meseguer, and V. Mulero
Evolution of the Inflammatory Response in Vertebrates: Fish TNF-{alpha} Is a Powerful Activator of Endothelial Cells but Hardly Activates Phagocytes
J. Immunol., October 1, 2008; 181(7): 5071 - 5081.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
S. Zuyderduyn, M. B. Sukkar, A. Fust, S. Dhaliwal, and J. K. Burgess
Treating asthma means treating airway smooth muscle cells
Eur. Respir. J., August 1, 2008; 32(2): 265 - 274.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
J. West and B. Damania
Upregulation of the TLR3 Pathway by Kaposi's Sarcoma-Associated Herpesvirus during Primary Infection
J. Virol., June 1, 2008; 82(11): 5440 - 5449.
[Abstract] [Full Text] [PDF]

Home page
 Postgrad. Med. J.Home page
I Sabroe, L C Parker, P M A Calverley, S K Dower, and M K B Whyte
Pathological networking: a new approach to understanding COPD
Postgrad. Med. J., May 1, 2008; 84(991): 259 - 264.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
V. Muller, D. Viemann, M. Schmidt, N. Endres, S. Ludwig, M. Leverkus, J. Roth, and M. Goebeler
Candida albicans Triggers Activation of Distinct Signaling Pathways to Establish a Proinflammatory Gene Expression Program in Primary Human Endothelial Cells
J. Immunol., December 15, 2007; 179(12): 8435 - 8445.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
S. Siddiqui, F. Hollins, S. Saha, and C. E. Brightling
Inflammatory cell microlocalisation and airway dysfunction: cause and effect?
Eur. Respir. J., December 1, 2007; 30(6): 1043 - 1056.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
I. Sabroe, L. C. Parker, S. K. Dower, and M. K. B. Whyte
Practical and Conceptual Models of Chronic Obstructive Pulmonary Disease
Proceedings of the ATS, December 1, 2007; 4(8): 606 - 610.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
I. Sabroe, L. C Parker, P. M A Calverley, S. K Dower, and M. K B Whyte
Pathological networking: a new approach to understanding COPD
Thorax, August 1, 2007; 62(8): 733 - 738.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
N. Chaudhuri, M. K. B. Whyte, and I. Sabroe
Reducing the Toll of Inflammatory Lung Disease
Chest, May 1, 2007; 131(5): 1550 - 1556.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
I. Sabroe, L. C. Parker, D. H. Dockrell, D. E. Davies, S. K. Dower, and M. K. B. Whyte
Targeting the Networks that Underpin Contiguous Immunity in Asthma and Chronic Obstructive Pulmonary Disease
Am. J. Respir. Crit. Care Med., February 15, 2007; 175(4): 306 - 311.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Copyright © 2006 by The Federation of American Societies for Experimental Biology.