FASEB J.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (Rapid PDF)
Right arrow All Versions of this Article:
fj.05-5639fjev1
20/12/2162    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Berbée, J. F. P.
Right arrow Articles by Rensen, P. C. N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Berbée, J. F. P.
Right arrow Articles by Rensen, P. C. N.
Published online before print August 25, 2006 as doi: 10.1096/fj.05-5639fje.

Apolipoprotein CI stimulates the response to lipopolysaccharide and reduces Mortality in Gram-negative sepsis

Jimmy F. P. Berbée, Caroline C. van der Hoogt, Robert Kleemann, Emile F. Schippers, Richard L. Kitchens, Jaap T. van Dissel, Irma A. J. M. Bakker-Woudenberg, Louis M. Havekes, and Patrick C. N. Rensen

E-mail contact: p.c.n.rensen@lumc.nl

Gram-negative sepsis is a major death cause in intensive care units. Accumulating evidence indicates the protective role of plasma lipoproteins such as high-density lipoprotein (HDL) in sepsis. It has recently been shown that septic HDL is almost depleted from apolipoprotein CI (apoCI), suggesting that apoCI may be a protective factor in sepsis. Sequence analysis revealed that apoCI possesses a highly conserved consensus KVKEKLK binding motif for lipopolysaccharide (LPS), an outer-membrane component of Gram-negative bacteria. Through avid binding to LPS involving this motif, apoCI improved the presentation of LPS to macrophages in vitro and in mice, thereby stimulating the inflammatory response to LPS. Moreover, apoCI dose-dependently increased the early inflammatory response to Klebsiella pneumoniae-induced pneumonia, reduced the number of circulating bacteria, and protected mice against fatal sepsis. Our data support the hypothesis that apoCI is a physiological protector against infection by enhancing the early inflammatory response to LPS and suggest that timely increase of apoCI levels could be used to efficiently prevent and treat early sepsis.--Berbée, J. F. P., van der Hoogt, C. C., Kleemann, R., Schippers, E. F., Kitchens, R. L., van Dissel, J. T., Bakker-Woudenberg, I. A. J. M., Havekes, L. M., Rensen, P. C. N. Apolipoprotein CI stimulates the response to lipopolysaccharide and reduces mortality in Gram-negative sepsis.




This article has been cited by other articles:


Home page
 Innate ImmunityHome page
P. A. Thompson, J. F.P. Berbee, P. C.N. Rensen, and R. L. Kitchens
Apolipoprotein A-II augments monocyte responses to LPS by suppressing the inhibitory activity of LPS-binding protein
Innate Immunity, December 1, 2008; 14(6): 365 - 374.
[Abstract] [PDF]

Home page
 J. Lipid Res.Home page
K. Abildayeva, J. F. P. Berbee, A. Blokland, P. J. Jansen, F. J. Hoek, O. Meijer, D. Lutjohann, T. Gautier, T. Pillot, J. De Vente, et al.
Human apolipoprotein C-I expression in mice impairs learning and memory functions
J. Lipid Res., April 1, 2008; 49(4): 856 - 869.
[Abstract] [Full Text] [PDF]

Home page
 J. Gerontol. A Biol. Sci. Med. Sci.Home page
J. F. P. Berbee, S. P. Mooijaart, A. J. M. de Craen, L. M. Havekes, D. van Heemst, P. C. N. Rensen, and R. G. J. Westendorp
Plasma Apolipoprotein CI Protects Against Mortality From Infection in Old Age
J. Gerontol. A Biol. Sci. Med. Sci., February 1, 2008; 63(2): 122 - 126.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
M. Westerterp, J. F.P. Berbee, N. M.M. Pires, G. J.D. van Mierlo, R. Kleemann, J. A. Romijn, L. M. Havekes, and P. C.N. Rensen
Apolipoprotein C-I Is Crucially Involved in Lipopolysaccharide-Induced Atherosclerosis Development in Apolipoprotein E Knockout Mice
Circulation, November 6, 2007; 116(19): 2173 - 2181.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
M. Westerterp, J. F. P. Berbee, D. J. M. Delsing, M. C. Jong, M. J. J. Gijbels, V. E. H. Dahlmans, E. H. Offerman, J. A. Romijn, L. M. Havekes, and P. C. N. Rensen
Apolipoprotein C-I binds free fatty acids and reduces their intracellular esterification
J. Lipid Res., June 1, 2007; 48(6): 1353 - 1361.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Copyright © 2006 by The Federation of American Societies for Experimental Biology.