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The FASEB Journal, Vol 9, 484-496, Copyright © 1995 by The Federation of American Societies for Experimental Biology

REVIEWS

Protein kinase C and lipid signaling for sustained cellular responses

Y Nishizuka
Biosignal Research Center, Kobe University, Japan.

Since the second messenger role was proposed for the products of inositol phospholipid hydrolysis, considerable progress has been made in our understanding of the biochemical mechanism of the intracellular signaling network. It is now becoming evident that stimulation of a cell surface receptor initiates a degradation cascade of various membrane lipid constituents. Many of their metabolites have potential to induce, intensify, and prolong the activation of protein kinase C that is needed for sustained cellular responses.


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 Cancer Res.Home page
T. Hara, Y. Saito, T. Hirai, K. Nakamura, K. Nakao, M. Katsuki, and K. Chida
Deficiency of Protein Kinase C{alpha} in Mice Results in Impairment of Epidermal Hyperplasia and Enhancement of Tumor Formation in Two-Stage Skin Carcinogenesis
Cancer Res., August 15, 2005; 65(16): 7356 - 7362.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
T. Seki, N. Adachi, Y. Ono, H. Mochizuki, K. Hiramoto, T. Amano, H. Matsubayashi, M. Matsumoto, H. Kawakami, N. Saito, et al.
Mutant Protein Kinase C{gamma} Found in Spinocerebellar Ataxia Type 14 Is Susceptible to Aggregation and Causes Cell Death
J. Biol. Chem., August 12, 2005; 280(32): 29096 - 29106.
[Abstract] [Full Text] [PDF]

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 PhysiologyHome page
A. J. Rose and E. A. Richter
Skeletal Muscle Glucose Uptake During Exercise: How is it Regulated?
Physiology, August 1, 2005; 20(4): 260 - 270.
[Abstract] [Full Text] [PDF]

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 EndocrinologyHome page
M. Jove, A. Planavila, J. C. Laguna, and M. Vazquez-Carrera
Palmitate-Induced Interleukin 6 Production Is Mediated by Protein Kinase C and Nuclear-Factor {kappa}B Activation and Leads to Glucose Transporter 4 Down-Regulation in Skeletal Muscle Cells
Endocrinology, July 1, 2005; 146(7): 3087 - 3095.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
S. Itoh, B. Ding, C. P. Bains, N. Wang, Y. Takeishi, T. Jalili, G. L. King, R. A. Walsh, C. Yan, and J.-i. Abe
Role of p90 Ribosomal S6 Kinase (p90RSK) in Reactive Oxygen Species and Protein Kinase C {beta} (PKC-{beta})-mediated Cardiac Troponin I Phosphorylation
J. Biol. Chem., June 24, 2005; 280(25): 24135 - 24142.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
C.-H. Tang, R.-S. Yang, and W.-M. Fu
Prostaglandin E2 Stimulates Fibronectin Expression through EP1 Receptor, Phospholipase C, Protein Kinase C{alpha}, and c-Src Pathway in Primary Cultured Rat Osteoblasts
J. Biol. Chem., June 17, 2005; 280(24): 22907 - 22916.
[Abstract] [Full Text] [PDF]

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 J. Neurosci.Home page
S. Sajikumar, S. Navakkode, T. C. Sacktor, and J. U. Frey
Synaptic Tagging and Cross-Tagging: The Role of Protein Kinase M{zeta} in Maintaining Long-Term Potentiation But Not Long-Term Depression
J. Neurosci., June 15, 2005; 25(24): 5750 - 5756.
[Abstract] [Full Text] [PDF]

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 J. Immunol.Home page
M. W. Nasser, R. J. Marjoram, S. L. Brown, and R. M. Richardson
Cross-Desensitization among CXCR1, CXCR2, and CCR5: Role of Protein Kinase C-{epsilon}
J. Immunol., June 1, 2005; 174(11): 6927 - 6933.
[Abstract] [Full Text] [PDF]

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 J. Immunol.Home page
Z. Peng and M. A. Beaven
An Essential Role for Phospholipase D in the Activation of Protein Kinase C and Degranulation in Mast Cells
J. Immunol., May 1, 2005; 174(9): 5201 - 5208.
[Abstract] [Full Text] [PDF]

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 J. Lipid Res.Home page
A. Denys, A. Hichami, and N. A. Khan
n-3 PUFAs modulate T-cell activation via protein kinase C-{alpha} and -{varepsilon} and the NF-{kappa}B signaling pathway
J. Lipid Res., April 1, 2005; 46(4): 752 - 758.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
J. van Baal, J. de Widt, N. Divecha, and W. J. van Blitterswijk
Translocation of Diacylglycerol Kinase {theta} from Cytosol to Plasma Membrane in Response to Activation of G Protein-coupled Receptors and Protein Kinase C
J. Biol. Chem., March 18, 2005; 280(11): 9870 - 9878.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
S. J. Khundmiri, W. L. Dean, K. R. McLeish, and E. D. Lederer
Parathyroid Hormone-mediated Regulation of Na+-K+-ATPase Requires ERK-dependent Translocation of Protein Kinase C{alpha}
J. Biol. Chem., March 11, 2005; 280(10): 8705 - 8713.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
S. Amos, P. M. Martin, G. A. Polar, S. J. Parsons, and I. M. Hussaini
Phorbol 12-Myristate 13-Acetate Induces Epidermal Growth Factor Receptor Transactivation via Protein Kinase C{delta}/c-Src Pathways in Glioblastoma Cells
J. Biol. Chem., March 4, 2005; 280(9): 7729 - 7738.
[Abstract] [Full Text] [PDF]

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 J. Pharmacol. Exp. Ther.Home page
W. B. Bollag, X. Zhong, M. E. Dodd, D. M. Hardy, X. Zheng, and W. T. Allred
Phospholipase D Signaling and Extracellular Signal-Regulated Kinase-1 and -2 Phosphorylation (Activation) Are Required for Maximal Phorbol Ester-Induced Transglutaminase Activity, a Marker of Keratinocyte Differentiation
J. Pharmacol. Exp. Ther., March 1, 2005; 312(3): 1223 - 1231.
[Abstract] [Full Text] [PDF]

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 GENES CELLSHome page
T. Seki, H. Matsubayashi, T. Amano, Y. Shirai, N. Saito, and N. Sakai
Phosphorylation of PKC activation loop plays an important role in receptor-mediated translocation of PKC
Genes Cells, March 1, 2005; 10(3): 225 - 239.
[Abstract] [Full Text] [PDF]

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 J. Immunol.Home page
P. Lin, E. J. Welch, X.-P. Gao, A. B. Malik, and R. D. Ye
Lysophosphatidylcholine Modulates Neutrophil Oxidant Production through Elevation of Cyclic AMP
J. Immunol., March 1, 2005; 174(5): 2981 - 2989.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
J.-S. Chang, S.-K. Kim, T.-K. Kwon, S. S. Bae, D. S. Min, Y. H. Lee, S.-O. Kim, J.-K. Seo, J. H. Choi, and P.-G. Suh
Pleckstrin Homology Domains of Phospholipase C-{gamma}1 Directly Interact with {beta}-Tubulin for Activation of Phospholipase C-{gamma}1 and Reciprocal Modulation of {beta}-Tubulin Function in Microtubule Assembly
J. Biol. Chem., February 25, 2005; 280(8): 6897 - 6905.
[Abstract] [Full Text] [PDF]

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 J. Leukoc. Biol.Home page
E. Corsini, M. Racchi, E. Sinforiani, L. Lucchi, B. Viviani, G. E. Rovati, S. Govoni, C. L. Galli, and M. Marinovich
Age-related decline in RACK-1 expression in human leukocytes is correlated to plasma levels of dehydroepiandrosterone
J. Leukoc. Biol., February 1, 2005; 77(2): 247 - 256.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Endocrinol. Metab.Home page
I. Talior, T. Tennenbaum, T. Kuroki, and H. Eldar-Finkelman
PKC-{delta}-dependent activation of oxidative stress in adipocytes of obese and insulin-resistant mice: role for NADPH oxidase
Am J Physiol Endocrinol Metab, February 1, 2005; 288(2): E405 - E411.
[Abstract] [Full Text] [PDF]

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 J. Neurosci.Home page
Y. Chen, A. R. Cantrell, R. O. Messing, T. Scheuer, and W. A. Catterall
Specific Modulation of Na+ Channels in Hippocampal Neurons by Protein Kinase C{epsilon}
J. Neurosci., January 12, 2005; 25(2): 507 - 513.
[Abstract] [Full Text] [PDF]

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 Am. J. Pathol.Home page
D. L. Wheeler, P. J. Reddig, K. J. Ness, C. P. Leith, T. D. Oberley, and A. K. Verma
Overexpression of Protein Kinase C-{epsilon} in the Mouse Epidermis Leads to a Spontaneous Myeloproliferative-Like Disease
Am. J. Pathol., January 1, 2005; 166(1): 117 - 126.
[Abstract] [Full Text] [PDF]

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 BloodHome page
T. Hitomi, J. Zhang, L. M. Nicoletti, A. C. G. Grodzki, M. C. Jamur, C. Oliver, and R. P. Siraganian
Phospholipase D1 regulates high-affinity IgE receptor-induced mast cell degranulation
Blood, December 15, 2004; 104(13): 4122 - 4128.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
T. Dobransky, A. Doherty-Kirby, A.-R. Kim, D. Brewer, G. Lajoie, and R. J. Rylett
Protein Kinase C Isoforms Differentially Phosphorylate Human Choline Acetyltransferase Regulating Its Catalytic Activity
J. Biol. Chem., December 10, 2004; 279(50): 52059 - 52068.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Renal Physiol.Home page
R. Pedrosa, P. Gomes, U. Hopfer, P. A. Jose, and P. Soares-da-Silva
Gi{alpha}3 protein-coupled dopamine D3 receptor-mediated inhibition of renal NHE3 activity in SHR proximal tubular cells is a PLC-PKC-mediated event
Am J Physiol Renal Physiol, November 1, 2004; 287(5): F1059 - F1066.
[Abstract] [Full Text] [PDF]

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 BloodHome page
T. R. Hundley, A. M. Gilfillan, C. Tkaczyk, M. V. Andrade, D. D. Metcalfe, and M. A. Beaven
Kit and Fc{epsilon}RI mediate unique and convergent signals for release of inflammatory mediators from human mast cells
Blood, October 15, 2004; 104(8): 2410 - 2417.
[Abstract] [Full Text] [PDF]

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 GENES CELLSHome page
N. Sakai, H. Tsubokawa, M. Matsuzaki, T. Kajimoto, E. Takahashi, Y. Ren, S. Ohmori, Y. Shirai, H. Matsubayashi, J. Chen, et al.
Propagation of {gamma}PKC translocation along the dendrites of Purkinje cell in {gamma}PKC-GFP transgenic mice
Genes Cells, October 1, 2004; 9(10): 945 - 957.
[Abstract] [Full Text] [PDF]

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 Cereb CortexHome page
N. Higo, T. Oishi, A. Yamashita, K. Matsuda, and M. Hayashi
Cell Type- and Region-specific Expression of Neurogranin mRNA in the Cerebral Cortex of the Macaque Monkey
Cereb Cortex, October 1, 2004; 14(10): 1134 - 1143.
[Abstract] [Full Text] [PDF]

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 Mol. Cell. Biol.Home page
T. Efimova, A.-M. Broome, and R. L. Eckert
Protein Kinase C{delta} Regulates Keratinocyte Death and Survival by Regulating Activity and Subcellular Localization of a p38{delta}-Extracellular Signal-Regulated Kinase 1/2 Complex
Mol. Cell. Biol., September 15, 2004; 24(18): 8167 - 8183.
[Abstract] [Full Text] [PDF]

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 J. Immunol.Home page
R. S. Soloff, C. Katayama, M. Y. Lin, J. R. Feramisco, and S. M. Hedrick
Targeted Deletion of Protein Kinase C {lambda} Reveals a Distribution of Functions between the Two Atypical Protein Kinase C Isoforms
J. Immunol., September 1, 2004; 173(5): 3250 - 3260.
[Abstract] [Full Text] [PDF]

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 Cancer Res.Home page
J. Koivunen, V. Aaltonen, S. Koskela, P. Lehenkari, M. Laato, and J. Peltonen
Protein Kinase C {alpha}/{beta} Inhibitor Go6976 Promotes Formation of Cell Junctions and Inhibits Invasion of Urinary Bladder Carcinoma Cells
Cancer Res., August 15, 2004; 64(16): 5693 - 5701.
[Abstract] [Full Text] [PDF]

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 Cancer Res.Home page
X.-H. Jiang, S.-P. Tu, J.-T. Cui, M. C. M. Lin, H. H. X. Xia, W. M. Wong, A. O.-O. Chan, M. F. Yuen, S.-H. Jiang, S.-K. Lam, et al.
Antisense Targeting Protein Kinase C {alpha} and {beta}1 Inhibits Gastric Carcinogenesis
Cancer Res., August 15, 2004; 64(16): 5787 - 5794.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
O. Rey, J. R. Reeve Jr., E. Zhukova, J. Sinnett-Smith, and E. Rozengurt
G Protein-coupled Receptor-mediated Phosphorylation of the Activation Loop of Protein Kinase D: DEPENDENCE ON PLASMA MEMBRANE TRANSLOCATION AND PROTEIN KINASE C{epsilon}
J. Biol. Chem., August 13, 2004; 279(33): 34361 - 34372.
[Abstract] [Full Text] [PDF]


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