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The FASEB Journal, Vol 8, 1314-1325, Copyright © 1994 by The Federation of American Societies for Experimental Biology

REVIEWS

The interleukin-1 family: 10 years of discovery

CA Dinarello
Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts.

Ten years ago the cloning of two interleukin-1 molecules (IL-1 alpha and IL-1 beta) resolved the question of whether a single polypeptide could evoke a wide variety of biological effects. During the past decade, the biology of IL-1 has greatly expanded our understanding of how the host responds to external challenges, such as injury and infection, as well as its role in several diseases. We learned of the remarkable potency of IL-1 in the femtomolar range and of its ability to induce a response by triggering only one or two receptors per cell. Unexpectedly, the IL-1 family of genes, receptors and associated molecules have been linked to those of Drosophila, nematodes, and microorganisms and IL-1 signal transduction is similar to that observed after cellular stress. The cloning of IL-1 opened other avenues of fundamental biological interest. For example, in addition to the two agonist molecules IL-1 alpha and IL-1 beta, a third member of the IL-1 gene family is a specific, high affinity receptor antagonist (IL-1 receptor antagonist). That this third member of the IL-1 family inhibits the other two is characteristic of the tight control over production and activity exerted on IL-1. Although IL-1 contributes to the pathogenesis of many diseases, a small amount appears to be needed to combat infection and initiate healing processes. This article highlights 10 years of discoveries on IL-1.


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[Abstract] [Full Text] [PDF]

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Home page
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[Abstract] [Full Text] [PDF]

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Home page
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Home page
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[Full Text] [PDF]

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 IOVSHome page
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[Abstract] [Full Text]

Home page
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J. A. Melendez, J. M. Vinci, J. J. Jeffrey, and B. D. Wilcox
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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
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[Abstract] [Full Text] [PDF]

Home page
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Home page
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[Abstract] [Full Text]

Home page
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Home page
 J. Biol. Chem.Home page
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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
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J. Biol. Chem., February 18, 2000; 275(7): 4858 - 4864.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
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J. Immunol., January 15, 2000; 164(2): 1013 - 1019.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
B. Cambien, M.-A. Millet, H. Schmid-Antomarchi, N. Brossette, B. Rossi, and A. Schmid-Alliana
Src-Regulated Extracellular Signal-Related Kinase and Syk-Regulated c-Jun N-Terminal Kinase Pathways Act in Conjunction to Induce IL-1 Synthesis in Response to Microtubule Disruption in HL60 Cells
J. Immunol., November 1, 1999; 163(9): 5079 - 5085.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
M. Vinals, J. Martinez-Gonzalez, and L. Badimon
Regulatory Effects of HDL on Smooth Muscle Cell Prostacyclin Release
Arterioscler. Thromb. Vasc. Biol., October 1, 1999; 19(10): 2405 - 2411.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
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Intracellular IL-1 Receptor Antagonist Is Elevated in Human Dermal Fibroblasts That Overexpress Intracellular Precursor IL-1{alpha}
J. Immunol., October 1, 1999; 163(7): 3969 - 3975.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
H. Wang, O. Bloom, M. Zhang, J. M. Vishnubhakat, M. Ombrellino, J. Che, A. Frazier, H. Yang, S. Ivanova, L. Borovikova, et al.
HMG-1 as a Late Mediator of Endotoxin Lethality in Mice
Science, July 9, 1999; 285(5425): 248 - 251.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
R. F. Lodato, A. R. Khan, M. J. Zembowicz, N. W. Weisbrodt, T. A. Pressley, Y.-F. Li, J. A. Lodato, A. Zembowicz, and F. G. Moody
Roles of IL-1 and TNF in the decreased ileal muscle contractility induced by lipopolysaccharide
Am J Physiol Gastrointest Liver Physiol, June 1, 1999; 276(6): G1356 - G1362.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
W. P. Luk, Y. Zhang, T. D. White, F. A. Lue, C. Wu, C.-G. Jiang, L. Zhang, and H. Moldofsky
Adenosine: a Mediator of Interleukin-1beta -Induced Hippocampal Synaptic Inhibition
J. Neurosci., June 1, 1999; 19(11): 4238 - 4244.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
V. Baud, Z.-G. Liu, B. Bennett, N. Suzuki, Y. Xia, and M. Karin
Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain
Genes & Dev., May 15, 1999; 13(10): 1297 - 1308.
[Abstract] [Full Text]

Home page
 J. Immunol.Home page
H. F. Staats and F. A. Ennis Jr.
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J. Immunol., May 15, 1999; 162(10): 6141 - 6147.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
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Endocrinology, February 1, 1999; 140(2): 888 - 896.
[Abstract] [Full Text]

Home page
 J. Immunol.Home page
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J. Immunol., January 15, 1999; 162(2): 886 - 896.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Han, T. Meng, N. R. Murray, A. P. Fields, and A. R. Brasier
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J. Biol. Chem., January 8, 1999; 274(2): 939 - 947.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
A Bavelloni, S Santi, A Sirri, M Riccio, I Faenza, N Zini, S Cecchi, A Ferri, P Auron, N. Maraldi, et al.
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