HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Supplement Data All Versions of this Article: fj.06-7061comv1 21/2/393    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Bloch, I. Articles by Shai, Y. Search for Related Content PubMed PubMed Citation Articles by Bloch, I. Articles by Shai, Y. Related Collections Related Articles

T-Cell inactivation and immunosuppressive activity induced by HIV gp41 via novel interacting motif

Itai Bloch^*,1, Francisco J. Quintana^,1,2, Doron Gerber^*, Tomer Cohen^*, Irun R. Cohen and Yechiel Shai^*,3

^* Department of Biological Chemistry, and

Department of Immunology, the Weizmann Institute of Science, Rehovot, Israel

³Correspondence: Department of Biological Chemistry, the Weizmann Institute of Science, Rehovot, 76100 Israel. E-mail: yechiel.shai{at}weizmann.ac.il

Fusion peptide (FP) of the HIV gp41 molecule inserts into the T cell membrane during virus-cell fusion. FP also blocks the TCR/CD3 interaction needed for antigen-triggered T cell activation. Here we used in vitro (fluorescence and immunoprecipitation), in vivo (T cell mediated autoimmune disease adjuvant arthritis), and in silico methods to identify the FP-TCR novel interaction motif: the -helical transmembrane domain (TMD) of the TCR chain, and the ß-sheet 5–13 region of the 16 N-terminal aa of FP (FP_1–16). Deciphering the molecular mechanism of the immunosuppressive activity of FP provides a new potential target to overcome the immunosuppressant activity of HIV, and in addition a tool for down-regulating immune mediated inflammation.—Bloch, I., Quintana, F. J., Gerger, D., Cohen, T., Cohen, I. R., and Shai, Y. T-Cell inactivation and immunosuppressive activity induced by HIV gp41 via novel interacting motif.

Key Words: membrane proteins • protein-membrane interaction • peptide-membrane interaction • transmembrane domain • recognition within membranes

Related Articles

Interaction between HIV gp41 fusion peptide and T cell receptor: putting the puzzle pieces back together

Alexander B. Sigalov
FASEB J 2007 21: 1633-1634. [Full Text] [PDF]

This article has been cited by other articles:

				A. B. Sigalov Interaction between HIV gp41 fusion peptide and T cell receptor: putting the puzzle pieces back together FASEB J, June 1, 2007; 21(8): 1633 - 1634. [Full Text] [PDF]

				F. J. Quintana, D. Gerber, I. Bloch, I. R. Cohen, and Y. Shai Response to "Interaction between HIV gp41 fusion peptide and T cell receptor: putting the puzzle pieces back together" FASEB J, June 1, 2007; 21(8): 1635 - 1635. [Full Text] [PDF]