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(The FASEB Journal. 2007;21:325-332.)
© 2007 FASEB

Resolution of inflammation: state of the art, definitions and terms

Charles N. Serhan*,1, Sue D. Brain{dagger}, Christopher D. Buckley{ddagger}, Derek W. Gilroy§, Christopher Haslett||, Luke A. J. O’Neill, Mauro Perretti**, Adriano G. Rossi|| and John L. Wallace{dagger}{dagger}

* Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women’s Hospital and Harvard Medical School, Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, Massachusetts, USA;

{dagger} Cardiovascular Division, King’s College, New Hunt’s House, Guy’s Campus, London, UK;

{ddagger} Division of Immunity and Infection, MRC Center for Immune Regulation, University of Birmingham Medical School, Edgbaston, UK;

§ Centre for Clinical Pharmacology and Therapeutics, Division of Medicine, University College London, London, UK;

|| University of Edinburgh, MRC/Centre for Inflammation Research, The Queen’s Medical Research Institute, Edinburgh, UK;

School of Biochemistry and Immunology, Trinity College Dublin, Ireland;

** William Harvey Research Institute, Queen Mary University of London, Charterhouse Square, London, UK;

{dagger}{dagger} Inflammation Research Network, University of Calgary, Calgary, Alberta, Canada

1Correspondence: Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women’s Hospital and Harvard Medical School, Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, 75 Francis St., Thorn 724, Boston, MA, USA 02115. E-mail: cnserhan{at}zeus.bwh.harvard.edu

A recent focus meeting on Controlling Acute Inflammation was held in London, April 27–28, 2006, organized by D.W. Gilroy and S.D. Brain for the British Pharmacology Society. We concluded at the meeting that a consensus report was needed that addresses the rapid progress in this emerging field and details how the specific study of resolution of acute inflammation provides leads for novel anti-inflammatory therapeutics, as well as defines the terms and key components of interest in the resolution process within tissues as appreciated today. The inflammatory response protects the body against infection and injury but can itself become dysregulated with deleterious consequences to the host. It is now evident that endogenous biochemical pathways activated during defense reactions can counter-regulate inflammation and promote resolution. Hence, resolution is an active rather than a passive process, as once believed, which now promises novel approaches for the treatment of inflammation-associated diseases based on endogenous agonists of resolution.—Serhan, C. N., Brain, S. D., Buckley, C. D., Gilroy, D. W., Haslett, C., O’Neill, L. A. J., Perretti, M., Rossi, A. G., Wallace, J. L. Resolution of inflammation: state of the art, definitions and terms.


Key Words: anti-inflammatories • leukocytes • lipid mediators • chemokines • cytokines




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