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(The FASEB Journal. 2006;20:1293-1299.)
© 2006 FASEB

A brief history of RNAi: the silence of the genes

George L. Sen*,{dagger},1 and Helen M. Blau*,{dagger},{ddagger},1

* Department of Molecular Pharmacology,

{dagger} Baxter Laboratory in Genetic Pharmacology,

{ddagger} Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, USA

1Correspondence: Baxter Laboratory in Genetic Pharmacology, 269 Campus Dr., CCSR 4225A, Stanford University School of Medicine, Stanford, CA 94305, USA. E-mail: gsen{at}stanford.edu; hblau{at}stanford.edu

The use of the RNA interference (RNAi) pathway to eliminate gene products has greatly facilitated the understanding of gene function. Behind this remarkable pathway is an intricate network of proteins that ensures the degradation of the target mRNA. In this review, we explore the history of RNAi as well as highlighting recent discoveries.—Sen, G. L., Blau, H. M. A brief history of RNAi: the silence of the genes.


Key Words: Si RNA • shRNA • gene regulation • post-transitional gene silencing • dsRNA • mRNA degradation • mRNA decay centers • Argonaute • p-bodies




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