FASEB J.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Maines, M. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Maines, M. D.

The FASEB Journal, Vol 2, 2557-2568, Copyright © 1988 by The Federation of American Societies for Experimental Biology

REVIEWS

Heme oxygenase: function, multiplicity, regulatory mechanisms, and clinical applications

MD Maines
Department of Biophysics, University of Rochester School of Medicine, New York 14642.

In biological systems oxidation of heme is carried out by two isozymes of the microsomal heme oxygenase, HO-1 and HO-2. HO-1 is the commonly known heme oxygenase, the activity of which can be induced by up to 100- fold in response to a wide variety of stimuli (metals, heme, hormones, etc.). HO-2 was only recently discovered, and the isozyme appears to be uninducible. The two forms are products of two different genes and differ in their tissue expression. The primary structure of HO-1 and an HO-2 fragment of 91 amino acid residues show only 58% homology, but share a region with 100% secondary structure homology. This region is believed to be the catalytic site. Most likely, HO-1 gene is regulated in the same manner as metallothione in the gene. HO-1 has a heat shock regulatory element, and possibly many promoter elements, which bind to respective inducers and cause transcription of the gene. In vivo induction of HO-1 activity in the liver is accompanied by decreases in the total P-450 levels and, in a reconstituted system, cytochrome P- 450b heme can be quantitatively converted to biliverdin by HO-1 and HO- 2. The enzyme activity is inhibited in vivo for extended periods subsequent to binding of Zn- and Sn- protoporphyrins. This property appears useful for the suppression of bilirubin production. The metalloporphyrins, however, are not innocuous and cause major disruptions in cellular metabolism. In this review recent findings on heme oxygenase are highlighted.


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
A. Kumar, J. S. Deshane, D. K. Crossman, S. Bolisetty, B.-S. Yan, I. Kramnik, A. Agarwal, and A. J. C. Steyn
Heme Oxygenase-1-derived Carbon Monoxide Induces the Mycobacterium tuberculosis Dormancy Regulon
J. Biol. Chem., June 27, 2008; 283(26): 18032 - 18039.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
H. Zhao, R. J. Wong, T. C. Doyle, N. Nayak, H. J. Vreman, C. H. Contag, and D. K. Stevenson
Regulation of Maternal and Fetal Hemodynamics by Heme Oxygenase in Mice
Biol Reprod, April 1, 2008; 78(4): 744 - 751.
[Abstract] [Full Text] [PDF]

Home page
 Br J AnaesthHome page
K. Takemori, K. Kobayashi, and A. Sakamoto
Expression of pulmonary vasoactive factors after sevoflurane anaesthesia in rats: a quantitative real-time polymerase chain reaction study
Br. J. Anaesth., February 1, 2008; 100(2): 190 - 194.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
R. T. Kinobe, Y. Ji, J. Z. Vlahakis, R. Motterlini, J. F. Brien, W. A. Szarek, and K. Nakatsu
Effectiveness of Novel Imidazole-Dioxolane Heme Oxygenase Inhibitors in Renal Proximal Tubule Epithelial Cells
J. Pharmacol. Exp. Ther., December 1, 2007; 323(3): 763 - 770.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
X. Yang, P. J. Lee, L. Long, R. C. Trembath, and N. W. Morrell
BMP4 Induces HO-1 via a Smad-Independent, p38MAPK-Dependent Pathway in Pulmonary Artery Myocytes
Am. J. Respir. Cell Mol. Biol., November 1, 2007; 37(5): 598 - 605.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M.-H. Li, J.-H. Jang, H.-K. Na, Y.-N. Cha, and Y.-J. Surh
Carbon Monoxide Produced by Heme Oxygenase-1 in Response to Nitrosative Stress Induces Expression of Glutamate-Cysteine Ligase in PC12 Cells via Activation of Phosphatidylinositol 3-Kinase and Nrf2 Signaling
J. Biol. Chem., September 28, 2007; 282(39): 28577 - 28586.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Surg. Oncol.Home page
S.-S. Lo, S.-C. Lin, C.-W. Wu, J.-H. Chen, W.-I Yeh, M.-Y. Chung, and W.-Y. Lui
Heme Oxygenase-1 Gene Promoter Polymorphism is Associated with Risk of Gastric Adenocarcinoma and Lymphovascular Tumor Invasion
Ann. Surg. Oncol., August 1, 2007; 14(8): 2250 - 2256.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
G. E. Mann, D. J. Rowlands, F. Y.L. Li, P. de Winter, and R. C.M. Siow
Activation of endothelial nitric oxide synthase by dietary isoflavones: Role of NO in Nrf2-mediated antioxidant gene expression
Cardiovasc Res, July 15, 2007; 75(2): 261 - 274.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. D. Sheftel, S. F. Kim, and P. Ponka
Non-heme Induction of Heme Oxygenase-1 Does Not Alter Cellular Iron Metabolism
J. Biol. Chem., April 6, 2007; 282(14): 10480 - 10486.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
D.-J. Slebos, S. W. Ryter, M. van der Toorn, F. Liu, F. Guo, C. J. Baty, J. M. Karlsson, S. C. Watkins, H. P. Kim, X. Wang, et al.
Mitochondrial Localization and Function of Heme Oxygenase-1 in Cigarette Smoke-Induced Cell Death
Am. J. Respir. Cell Mol. Biol., April 1, 2007; 36(4): 409 - 417.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
Z. Guo, Z. Xia, J. Jiang, and J. H. McNeill
Downregulation of NADPH oxidase, antioxidant enzymes, and inflammatory markers in the heart of streptozotocin-induced diabetic rats by N-acetyl-L-cysteine
Am J Physiol Heart Circ Physiol, April 1, 2007; 292(4): H1728 - H1736.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
Y. Tanaka, J. M. Maher, C. Chen, and C. D. Klaassen
Hepatic Ischemia-Reperfusion Induces Renal Heme Oxygenase-1 via NF-E2-Related Factor 2 in Rats and Mice
Mol. Pharmacol., March 1, 2007; 71(3): 817 - 825.
[Abstract] [Full Text] [PDF]

Home page
 NeoReviewsHome page
R. J. Wong, D. K. Stevenson, C. E. Ahlfors, and H. J. Vreman
Neonatal Jaundice: Bilirubin Physiology and Clinical Chemistry
NeoReviews, February 1, 2007; 8(2): e58 - e67.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
H. B. Suliman, M. S. Carraway, L. G. Tatro, and C. A. Piantadosi
A new activating role for CO in cardiac mitochondrial biogenesis
J. Cell Sci., January 15, 2007; 120(2): 299 - 308.
[Abstract] [Full Text] [PDF]

Home page
 Ann. N. Y. Acad. Sci.Home page
G. JANCSO, B. CSEREPES, B. GASZ, L. BENKO, B. BORSICZKY, A. FERENC, M. KURTHY, B. RACZ, J. LANTOS, J. GAL, et al.
Expression and Protective Role of Heme Oxygenase-1 in Delayed Myocardial Preconditioning
Ann. N.Y. Acad. Sci., January 1, 2007; 1095(1): 251 - 261.
[Abstract] [Full Text] [PDF]

Home page
 Ann. N. Y. Acad. Sci.Home page
E.-H. KIM, H.-K. NA, and Y.-J. SURH
Upregulation of VEGF by 15-Deoxy-{Delta}12,14-Prostaglandin J2 via Heme Oxygenase-1 and ERK1/2 Signaling in MCF-7 Cells
Ann. N.Y. Acad. Sci., December 1, 2006; 1090(1): 375 - 384.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
R. T. Kinobe, R. A. Dercho, J. Z. Vlahakis, J. F. Brien, W. A. Szarek, and K. Nakatsu
Inhibition of the Enzymatic Activity of Heme Oxygenases by Azole-Based Antifungal Drugs
J. Pharmacol. Exp. Ther., October 1, 2006; 319(1): 277 - 284.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
H. Mosen, A. Salehi, R. Henningsson, and I. Lundquist
Nitric oxide inhibits, and carbon monoxide activates, islet acid {alpha}-glucoside hydrolase activities in parallel with glucose-stimulated insulin secretion.
J. Endocrinol., September 1, 2006; 190(3): 681 - 693.
[Abstract] [Full Text] [PDF]

Home page
 CJASNHome page
J. A. Jaffe and P. L. Kimmel
Chronic Nephropathies of Cocaine and Heroin Abuse: A Critical Review
Clin. J. Am. Soc. Nephrol., July 1, 2006; 1(4): 655 - 667.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
M. Guha, S. Kumar, V. Choubey, P. Maity, and U. Bandyopadhyay
Apoptosis in liver during malaria: role of oxidative stress and implication of mitochondrial pathway
FASEB J, June 1, 2006; 20(8): 1224 - 1226.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
S. W. Ryter, J. Alam, and A. M. K. Choi
Heme Oxygenase-1/Carbon Monoxide: From Basic Science to Therapeutic Applications
Physiol Rev, April 1, 2006; 86(2): 583 - 650.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. W. Chung, Y.-H. Chen, S.-F. Yet, M. D. Layne, and M. A. Perrella
Endotoxin-Induced Down-Regulation of Elk-3 Facilitates Heme Oxygenase-1 Induction in Macrophages
J. Immunol., February 15, 2006; 176(4): 2414 - 2420.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
K.-J. Min, M.-s. Yang, S.-U. Kim, I. Jou, and E.-h. Joe
Astrocytes Induce Hemeoxygenase-1 Expression in Microglia: A Feasible Mechanism for Preventing Excessive Brain Inflammation
J. Neurosci., February 8, 2006; 26(6): 1880 - 1887.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
H. Morimatsu, T. Takahashi, K. Maeshima, K. Inoue, T. Kawakami, H. Shimizu, M. Takeuchi, M. Yokoyama, H. Katayama, and K. Morita
Increased heme catabolism in critically ill patients: correlation among exhaled carbon monoxide, arterial carboxyhemoglobin, and serum bilirubin IX{alpha} concentrations
Am J Physiol Lung Cell Mol Physiol, January 1, 2006; 290(1): L114 - L119.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
M. Ishikawa, M. Kajimura, T. Adachi, K. Maruyama, N. Makino, N. Goda, T. Yamaguchi, E. Sekizuka, and M. Suematsu
Carbon Monoxide From Heme Oxygenase-2 Is a Tonic Regulator Against NO-Dependent Vasodilatation in the Adult Rat Cerebral Microcirculation
Circ. Res., December 9, 2005; 97(12): e104 - e114.
[Abstract] [Full Text] [PDF]

Home page
 Evid Based Complement Alternat MedHome page
Y. Han, S.-J. Son, M. Akhalaia, A. Platonov, H.-J. Son, K.-H. Lee, Y.-S. Yun, and J.-Y. Song
Modulation of Radiation-Induced Disturbances of Antioxidant Defense Systems by Ginsan
Evid. Based Complement. Altern. Med., December 1, 2005; 2(4): 529 - 536.
[Abstract] [Full Text] [PDF]

Home page
 Pharmacol. Rev.Home page
L. Wu and R. Wang
Carbon Monoxide: Endogenous Production, Physiological Functions, and Pharmacological Applications
Pharmacol. Rev., December 1, 2005; 57(4): 585 - 630.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
Y. Izuhara, M. Nangaku, R. Inagi, N. Tominaga, T. Aizawa, K. Kurokawa, C. van Ypersele de Strihou, and T. Miyata
Renoprotective Properties of Angiotensin Receptor Blockers beyond Blood Pressure Lowering
J. Am. Soc. Nephrol., December 1, 2005; 16(12): 3631 - 3641.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
X. Zhang, P. Shan, S. Qureshi, R. Homer, R. Medzhitov, P. W. Noble, and P. J. Lee
Cutting Edge: TLR4 Deficiency Confers Susceptibility to Lethal Oxidant Lung Injury
J. Immunol., October 15, 2005; 175(8): 4834 - 4838.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
Y. Jin and A. M. K. Choi
Cytoprotection of Heme Oxygenase-1/Carbon Monoxide in Lung Injury
Proceedings of the ATS, October 1, 2005; 2(3): 232 - 235.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
T. Gulesserian, C. Wenzel, G. Endler, R. Sunder-Plassmann, C. Marsik, C. Mannhalter, N. Iordanova, M. Gyongyosi, J. Wojta, S. Mustafa, et al.
Clinical Restenosis after Coronary Stent Implantation Is Associated with the Heme Oxygenase-1 Gene Promoter Polymorphism and the Heme Oxygenase-1 +99G/C Variant
Clin. Chem., September 1, 2005; 51(9): 1661 - 1665.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. R. Vargas, M. Pehar, P. Cassina, L. Martinez-Palma, J. A. Thompson, J. S. Beckman, and L. Barbeito
Fibroblast Growth Factor-1 Induces Heme Oxygenase-1 via Nuclear Factor Erythroid 2-related Factor 2 (Nrf2) in Spinal Cord Astrocytes: CONSEQUENCES FOR MOTOR NEURON SURVIVAL
J. Biol. Chem., July 8, 2005; 280(27): 25571 - 25579.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
P. O. Berberat, Z. Dambrauskas, A. Gulbinas, T. Giese, N. Giese, B. Kunzli, F. Autschbach, S. Meuer, M. W. Buchler, and H. Friess
Inhibition of Heme Oxygenase-1 Increases Responsiveness of Pancreatic Cancer Cells to Anticancer Treatment
Clin. Cancer Res., May 15, 2005; 11(10): 3790 - 3798.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. Miralem, Z. Hu, M. D. Torno, K. M. Lelli, and M. D. Maines
Small Interference RNA-mediated Gene Silencing of Human Biliverdin Reductase, but Not That of Heme Oxygenase-1, Attenuates Arsenite-mediated Induction of the Oxygenase and Increases Apoptosis in 293A Kidney Cells
J. Biol. Chem., April 29, 2005; 280(17): 17084 - 17092.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. W. Chung, Y.-H. Chen, and M. A. Perrella
Role of Ets-2 in the Regulation of Heme Oxygenase-1 by Endotoxin
J. Biol. Chem., February 11, 2005; 280(6): 4578 - 4584.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
V. Govindaraju, H. Teoh, Q. Hamid, P. Cernacek, and M. E. Ward
Interaction between endothelial heme oxygenase-2 and endothelin-1 in altered aortic reactivity after hypoxia in rats
Am J Physiol Heart Circ Physiol, February 1, 2005; 288(2): H962 - H970.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
X.-m. Liu, K. J. Peyton, D. Ensenat, H. Wang, A. I. Schafer, J. Alam, and W. Durante
Endoplasmic Reticulum Stress Stimulates Heme Oxygenase-1 Gene Expression in Vascular Smooth Muscle: ROLE IN CELL SURVIVAL
J. Biol. Chem., January 14, 2005; 280(2): 872 - 877.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
I. Lim, S. J Gibbons, G. L. Lyford, S. M. Miller, P. R. Strege, M. G. Sarr, S. Chatterjee, J. H. Szurszewski, V. H. Shah, and G. Farrugia
Carbon monoxide activates human intestinal smooth muscle L-type Ca2+ channels through a nitric oxide-dependent mechanism
Am J Physiol Gastrointest Liver Physiol, January 1, 2005; 288(1): G7 - G14.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
C. L. Hartsfield, I. F. McMurtry, D. D. Ivy, K. G. Morris, S. Vidmar, D. M. Rodman, and K. A. Fagan
Cardioprotective and vasomotor effects of HO activity during acute and chronic hypoxia
Am J Physiol Heart Circ Physiol, November 1, 2004; 287(5): H2009 - H2015.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
D. Kubulus, F. Roesken, M. Amon, M. Rucker, M. Bauer, I. Bauer, and M. D. Menger
Mechanism of the delay phenomenon: tissue protection is mediated by heme oxygenase-1
Am J Physiol Heart Circ Physiol, November 1, 2004; 287(5): H2332 - H2340.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
R. Wegele, R. Tasler, Y. Zeng, M. Rivera, and N. Frankenberg-Dinkel
The Heme Oxygenase(s)-Phytochrome System of Pseudomonas aeruginosa
J. Biol. Chem., October 29, 2004; 279(44): 45791 - 45802.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
R. Stocker and J. F. Keaney Jr.
Role of Oxidative Modifications in Atherosclerosis
Physiol Rev, October 1, 2004; 84(4): 1381 - 1478.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
S. Rattan, R. A. Haj, and M. A. F. De Godoy
Mechanism of internal anal sphincter relaxation by CORM-1, authentic CO, and NANC nerve stimulation
Am J Physiol Gastrointest Liver Physiol, September 1, 2004; 287(3): G605 - G611.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
B. Fiedler and K. C Wollert
Interference of antihypertrophic molecules and signaling pathways with the Ca2+-calcineurin-NFAT cascade in cardiac myocytes
Cardiovasc Res, August 15, 2004; 63(3): 450 - 457.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
A. Almolki, C. Taille, G. F. Martin, P. J. Jose, C. Zedda, M. Conti, J. Megret, D. Henin, M. Aubier, and J. Boczkowski
Heme oxygenase attenuates allergen-induced airway inflammation and hyperreactivity in guinea pigs
Am J Physiol Lung Cell Mol Physiol, July 1, 2004; 287(1): L26 - L34.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
M. Schillinger, M. Exner, W. Mlekusch, M. Haumer, S. Sabeti, R. Ahmadi, O. Wagner, and E. Minar
Effect of Smoking on Restenosis during the 1st Year after Lower-Limb Endovascular Interventions
Radiology, June 1, 2004; 231(3): 831 - 838.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
G. Shen, V. Hebbar, S. Nair, C. Xu, W. Li, W. Lin, Y.-S. Keum, J. Han, M. A. Gallo, and A.-N. T. Kong
Regulation of Nrf2 Transactivation Domain Activity: THE DIFFERENTIAL EFFECTS OF MITOGEN-ACTIVATED PROTEIN KINASE CASCADES AND SYNERGISTIC STIMULATORY EFFECT OF Raf AND CREB-BINDING PROTEIN
J. Biol. Chem., May 28, 2004; 279(22): 23052 - 23060.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
M. Schillinger, M. Exner, E. Minar, W. Mlekusch, M. Mullner, C. Mannhalter, F. H. Bach, and O. Wagner
Heme oxygenase-1 genotype and restenosis after balloon angioplasty: a novel vascular protective factor
J. Am. Coll. Cardiol., March 17, 2004; 43(6): 950 - 957.
[Abstract] [Full Text] [PDF]

Home page
 Mol Hum ReprodHome page
D. Denschlag, R. Marculescu, G. Unfried, L.A. Hefler, M. Exner, A. Hashemi, E.-K. Riener, C. Keck, C.B. Tempfer, and O. Wagner
The size of a microsatellite polymorphism of the haem oxygenase 1 gene is associated with idiopathic recurrent miscarriage
Mol. Hum. Reprod., March 1, 2004; 10(3): 211 - 214.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
S. Gebel, B. Gerstmayer, A. Bosio, H.-J. Haussmann, E. V. Miert, and T. Muller
Gene expression profiling in respiratory tissues from rats exposed to mainstream cigarette smoke
Carcinogenesis, February 1, 2004; 25(2): 169 - 178.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. L. Pendrak, M. P. Chao, S. S. Yan, and D. D. Roberts
Heme Oxygenase in Candida albicans Is Regulated by Hemoglobin and Is Necessary for Metabolism of Exogenous Heme and Hemoglobin to {alpha}-Biliverdin
J. Biol. Chem., January 30, 2004; 279(5): 3426 - 3433.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y.-H. Weng, G. Yang, S. Weiss, and P. A. Dennery
Interaction between Heme Oxygenase-1 and -2 Proteins
J. Biol. Chem., December 19, 2003; 278(51): 50999 - 51005.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
J. Patel, N. Manjappa, R. Bhat, P. Mehrotra, M. Bhaskaran, and P. C. Singhal
Role of oxidative stress and heme oxygenase activity in morphine-induced glomerular epithelial cell growth
Am J Physiol Renal Physiol, November 1, 2003; 285(5): F861 - F869.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
S. Numazawa, M. Ishikawa, A. Yoshida, S. Tanaka, and T. Yoshida
Atypical protein kinase C mediates activation of NF-E2-related factor 2 in response to oxidative stress
Am J Physiol Cell Physiol, August 1, 2003; 285(2): C334 - C342.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
G. Farrugia, S. Lei, X. Lin, S. M. Miller, K. A. Nath, C. D. Ferris, M. Levitt, and J. H. Szurszewski
A major role for carbon monoxide as an endogenous hyperpolarizing factor in the gastrointestinal tract
PNAS, July 8, 2003; 100(14): 8567 - 8570.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
J. Fang, T. Sawa, T. Akaike, T. Akuta, S. K. Sahoo, G. Khaled, A. Hamada, and H. Maeda
In Vivo Antitumor Activity of Pegylated Zinc Protoporphyrin: Targeted Inhibition of Heme Oxygenase in Solid Tumor
Cancer Res., July 1, 2003; 63(13): 3567 - 3574.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
P. Maestrelli, C. Paska, M. Saetta, G. Turato, Y. Nowicki, S. Monti, B. Formichi, M. Miniati, and L.M. Fabbri
Decreased haem oxygenase-1 and increased inducible nitric oxide synthase in the lung of severe COPD patients
Eur. Respir. J., June 1, 2003; 21(6): 971 - 976.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T.-S. Lee, H.-L. Tsai, and L.-Y. Chau
Induction of Heme Oxygenase-1 Expression in Murine Macrophages Is Essential for the Anti-inflammatory Effect of Low Dose 15-Deoxy-{Delta}12,14-prostaglandin J2
J. Biol. Chem., May 23, 2003; 278(21): 19325 - 19330.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. Kietzmann, A. Samoylenko, and S. Immenschuh
Transcriptional Regulation of Heme Oxygenase-1 Gene Expression by MAP Kinases of the JNK and p38 Pathways in Primary Cultures of Rat Hepatocytes
J. Biol. Chem., May 9, 2003; 278(20): 17927 - 17936.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
Y.-H. Chen, S.-F. Yet, and M. A. Perrella
Role of Heme Oxygenase-1 in the Regulation of Blood Pressure and Cardiac Function
Experimental Biology and Medicine, May 1, 2003; 228(5): 447 - 453.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
S. Grasso, C. Scifo, V. Cardile, R. Gulino, and M. Reni