| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
B the sensor of oxidative stress?
Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California, San Diego, La Jolla, California 92093-0636, USA
1Correspondence: Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California, San Diego, 9500 Gilman Dr., La Jolla, CA 92093-0636, USA. E-mail: karinoffice{at}ucsd.edu
NF-
B is a dimeric transcription factor that is involved in the
regulation of a large number of genes that control various aspects of
the immune and inflammatory response. It is activated by a variety of
stimuli ranging from cytokines, to various forms of radiation, to
oxidative stress (such as exposure to H2O2).
Recent studies have advanced our understanding of the signal
transduction pathway leading to NF-B activation by cytokines and
will provide insights for the mechanism by which NF-B is regulated
by oxidative stress. An important question that is yet to be answered
is whether reactive oxygen species play a physiological role in NF-B
activation.—Li, N., Karin, M. Is NF-B the sensor of oxidative
stress?
Key Words: IB degradation • IKK • reactive oxygen species • tumor necrosis factor • GSH
This article has been cited by other articles:
|
|
 |
|
  A. Papi, M. Contoli, P. Gasparini, L. Bristot, M. R. Edwards, M. Chicca, M. Leis, A. Ciaccia, G. Caramori, S. L. Johnston, et al. Role of Xanthine Oxidase Activation and Reduced Glutathione Depletion in Rhinovirus Induction of Inflammation in Respiratory Epithelial Cells J. Biol. Chem., October 17, 2008; 283(42): 28595 - 28606. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Shen, E. Oesterling, A. Stromberg, M. Toborek, R. MacDonald, and B. Hennig Zinc Deficiency Induces Vascular Pro-Inflammatory Parameters Associated with NF-{kappa}B and PPAR Signaling J. Am. Coll. Nutr., October 1, 2008; 27(5): 577 - 587. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Lopez-Jaramillo, W. D. Arenas, R. G. Garcia, M. Y. Rincon, and M. Lopez Review: The role of the L-arginine-nitric oxide pathway in preeclampsia Therapeutic Advances in Cardiovascular Disease, August 1, 2008; 2(4): 261 - 275. [Abstract] [PDF]
|
|
|
|
|
|
K. Enesa, K. Ito, L. A. Luong, I. Thorbjornsen, C. Phua, Y. To, J. Dean, D. O. Haskard, J. Boyle, I. Adcock, et al. Hydrogen Peroxide Prolongs Nuclear Localization of NF-{kappa}B in Activated Cells by Suppressing Negative Regulatory Mechanisms J. Biol. Chem., July 4, 2008; 283(27): 18582 - 18590. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. C. Zangar, N. Bollinger, S. Verma, N. J. Karin, and Y. Lu The Nuclear Factor-{kappa}B Pathway Regulates Cytochrome P450 3A4 Protein Stability Mol. Pharmacol., June 1, 2008; 73(6): 1652 - 1658. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Dickinson, D. P Hancock, P. Petocz, A. Ceriello, and J. Brand-Miller High-glycemic index carbohydrate increases nuclear factor-{kappa}B activation in mononuclear cells of young, lean healthy subjects Am. J. Clinical Nutrition, May 1, 2008; 87(5): 1188 - 1193. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. A. Bloomer, K. E. Brown, G. R. Buettner, and K. C. Kregel Dysregulation of hepatic iron with aging: implications for heat stress-induced oxidative liver injury Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2008; 294(4): R1165 - R1174. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Masamune, T. Watanabe, K. Kikuta, K. Satoh, and T. Shimosegawa NADPH oxidase plays a crucial role in the activation of pancreatic stellate cells Am J Physiol Gastrointest Liver Physiol, January 1, 2008; 294(1): G99 - G108. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. J. Hawkins, L. A. Solt, I. Chowdhury, A. S. Kazi, M. R. Abid, W. C. Aird, M. J. May, J. K. Foskett, and M. Madesh G Protein-Coupled Receptor Ca2+-Linked Mitochondrial Reactive Oxygen Species Are Essential for Endothelial/Leukocyte Adherence Mol. Cell. Biol., November 1, 2007; 27(21): 7582 - 7593. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Carluccio, M. A. Ancora, M. Massaro, M. Carluccio, E. Scoditti, A. Distante, C. Storelli, and R. De Caterina Homocysteine induces VCAM-1 gene expression through NF-{kappa}B and NAD(P)H oxidase activation: protective role of Mediterranean diet polyphenolic antioxidants Am J Physiol Heart Circ Physiol, October 1, 2007; 293(4): H2344 - H2354. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Mandang, U. Manuelpillai, and E. M Wallace Oxidative stress increases placental and endothelial cell activin A secretion J. Endocrinol., March 1, 2007; 192(3): 485 - 493. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. L. Figarola, N. Shanmugam, R. Natarajan, and S. Rahbar Anti-Inflammatory Effects of the Advanced Glycation End Product Inhibitor LR-90 in Human Monocytes Diabetes, March 1, 2007; 56(3): 647 - 655. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. J. H. Mountain, M. Singh, B. Menon, and K. Singh Interleukin-1beta increases expression and activity of matrix metalloproteinase-2 in cardiac microvascular endothelial cells: role of PKC{alpha}/beta1 and MAPKs Am J Physiol Cell Physiol, February 1, 2007; 292(2): C867 - C875. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Pacher, J. S. Beckman, and L. Liaudet Nitric Oxide and Peroxynitrite in Health and Disease Physiol Rev, January 1, 2007; 87(1): 315 - 424. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 U. M. Fischer, A. Antonyan, W. Bloch, and U. Mehlhorn Impact of antioxidative treatment on nuclear factor kappa-B regulation during myocardial ischemia-reperfusion Interactive CardioVascular and Thoracic Surgery, October 1, 2006; 5(5): 531 - 535. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Li, N. Maeda, and M. A. Beck Vitamin C Deficiency Increases the Lung Pathology of Influenza Virus-Infected Gulo-/- Mice J. Nutr., October 1, 2006; 136(10): 2611 - 2616. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. R. Willsky, L.-H. Chi, Y. Liang, D. P. Gaile, Z. Hu, and D. C. Crans Diabetes-altered gene expression in rat skeletal muscle corrected by oral administration of vanadyl sulfate Physiol Genomics, September 14, 2006; 26(3): 192 - 201. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H.-M. Shen and S. Pervaiz TNF receptor superfamily-induced cell death: redox-dependent execution FASEB J, August 1, 2006; 20(10): 1589 - 1598. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. J. Crack, J. M. Taylor, U. Ali, A. Mansell, and P. J. Hertzog Potential Contribution of NF-{kappa}B in Neuronal Cell Death in the Glutathione Peroxidase-1 Knockout Mouse in Response to Ischemia-Reperfusion Injury Stroke, June 1, 2006; 37(6): 1533 - 1538. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Vogler, J. Pahnke, S. Rousset, D. Ricquier, H. Moch, B. Miroux, and S. M. Ibrahim Uncoupling Protein 2 Has Protective Function during Experimental Autoimmune Encephalomyelitis Am. J. Pathol., May 1, 2006; 168(5): 1570 - 1575. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. N. Islam and C. R. Mendelson Permissive Effects of Oxygen on Cyclic AMP and Interleukin-1 Stimulation of Surfactant Protein A Gene Expression Are Mediated by Epigenetic Mechanisms Mol. Cell. Biol., April 15, 2006; 26(8): 2901 - 2912. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Okamoto, Y. Iwamoto, and Y. Maru Oxidative Stress-Responsive Transcription Factor ATF3 Potentially Mediates Diabetic Angiopathy Mol. Cell. Biol., February 1, 2006; 26(3): 1087 - 1097. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. T. Resch, C. Oxvig, L. K. Bale, and C. A. Conover Stress-Activated Signaling Pathways Mediate the Stimulation of Pregnancy-Associated Plasma Protein-A Expression in Cultured Human Fibroblasts Endocrinology, February 1, 2006; 147(2): 885 - 890. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Conover, L. K. Bale, S. C. Harrington, Z. T. Resch, M. T. Overgaard, and C. Oxvig Cytokine stimulation of pregnancy-associated plasma protein A expression in human coronary artery smooth muscle cells: inhibition by resveratrol Am J Physiol Cell Physiol, January 1, 2006; 290(1): C183 - C188. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Levrand, B. Pesse, F. Feihl, B. Waeber, P. Pacher, J. Rolli, M.-D. Schaller, and L. Liaudet Peroxynitrite Is a Potent Inhibitor of NF-{kappa}B Activation Triggered by Inflammatory Stimuli in Cardiac and Endothelial Cell Lines J. Biol. Chem., October 14, 2005; 280(41): 34878 - 34887. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Liu, D. S. Chi, C. Li, H. K. Hall, D. M. Milhorn, and G. Krishnaswamy HIV-1 Tat protein-induced VCAM-1 expression in human pulmonary artery endothelial cells and its signaling Am J Physiol Lung Cell Mol Physiol, August 1, 2005; 289(2): L252 - L260. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Cacicedo, S. Benjachareowong, E. Chou, N. B. Ruderman, and Y. Ido Palmitate-Induced Apoptosis in Cultured Bovine Retinal Pericytes: Roles of NAD(P)H Oxidase, Oxidant Stress, and Ceramide Diabetes, June 1, 2005; 54(6): 1838 - 1845. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Yan and B. F. Hales Activator Protein-1 (AP-1) DNA Binding Activity Is Induced by Hydroxyurea in Organogenesis Stage Mouse Embryos Toxicol. Sci., June 1, 2005; 85(2): 1013 - 1023. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Panopoulos, M. Harraz, J. F. Engelhardt, and E. Zandi Iron-mediated H2O2 Production as a Mechanism for Cell Type-specific Inhibition of Tumor Necrosis Factor {alpha}-Induced but Not Interleukin-1{beta}-induced I{kappa}B Kinase Complex/Nuclear Factor-{kappa}B Activation J. Biol. Chem., January 28, 2005; 280(4): 2912 - 2923. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Liu, Z. Popovich, and D. M. Templeton Global Genomic Approaches to the Iron-Regulated Proteome Ann. Clin. Lab. Sci., January 1, 2005; 35(3): 230 - 239. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Stocker and J. F. Keaney Jr. Role of Oxidative Modifications in Atherosclerosis Physiol Rev, October 1, 2004; 84(4): 1381 - 1478. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Storz, H. Doppler, and A. Toker Activation Loop Phosphorylation Controls Protein Kinase D-Dependent Activation of Nuclear Factor {kappa}B Mol. Pharmacol., October 1, 2004; 66(4): 870 - 879. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. Kennedy, S. Memet, and P. G. Wells Antisense Evidence for Nuclear Factor-{kappa}B-Dependent Embryopathies Initiated by Phenytoin-Enhanced Oxidative Stress Mol. Pharmacol., September 1, 2004; 66(3): 404 - 412. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Sarkar, Y. Sreenivasan, G. T. Ramesh, and S. K. Manna {beta}-D-Glucoside Suppresses Tumor Necrosis Factor-induced Activation of Nuclear Transcription Factor {kappa}B but Potentiates Apoptosis J. Biol. Chem., August 6, 2004; 279(32): 33768 - 33781. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Fujioka, C. Schmidt, G. M. Sclabas, Z. Li, H. Pelicano, B. Peng, A. Yao, J. Niu, W. Zhang, D. B. Evans, et al. Stabilization of p53 Is a Novel Mechanism for Proapoptotic Function of NF-{kappa}B J. Biol. Chem., June 25, 2004; 279(26): 27549 - 27559. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Storz, H. Doppler, and A. Toker Protein Kinase C{delta} Selectively Regulates Protein Kinase D-Dependent Activation of NF-{kappa}B in Oxidative Stress Signaling Mol. Cell. Biol., April 1, 2004; 24(7): 2614 - 2626. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Zhang and F. Chen Reactive Oxygen Species (ROS), Troublemakers between Nuclear Factor-{kappa}B (NF-{kappa}B) and c-Jun NH2-terminal Kinase (JNK) Cancer Res., March 15, 2004; 64(6): 1902 - 1905. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. G. Passerini, D. C. Polacek, C. Shi, N. M. Francesco, E. Manduchi, G. R. Grant, W. F. Pritchard, S. Powell, G. Y. Chang, C. J. Stoeckert Jr., et al. Coexisting proinflammatory and antioxidative endothelial transcription profiles in a disturbed flow region of the adult porcine aorta PNAS, February 24, 2004; 101(8): 2482 - 2487. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Asehnoune, D. Strassheim, S. Mitra, J. Y. Kim, and E. Abraham Involvement of Reactive Oxygen Species in Toll-Like Receptor 4-Dependent Activation of NF-{kappa}B J. Immunol., February 15, 2004; 172(4): 2522 - 2529. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. T. Sadikot, H. Zeng, F. E. Yull, B. Li, D.-s. Cheng, D. S. Kernodle, E. D. Jansen, C. H. Contag, B. H. Segal, S. M. Holland, et al. p47phox Deficiency Impairs NF-{kappa}B Activation and Host Defense in Pseudomonas Pneumonia J. Immunol., February 1, 2004; 172(3): 1801 - 1808. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Jeong, T.-S. Chang, E. S. Boja, H. M. Fales, and S. G. Rhee Roles of TRP14, a Thioredoxin-related Protein in Tumor Necrosis Factor-{alpha} Signaling Pathways J. Biol. Chem., January 30, 2004; 279(5): 3151 - 3159. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. S. Frey and A. B. Malik Oxidant signaling in lung cells Am J Physiol Lung Cell Mol Physiol, January 1, 2004; 286(1): L1 - L3. [Full Text] [PDF]
|
|
|
|
|
|
C. Pantano, P. Shrivastava, B. McElhinney, and Y. Janssen-Heininger Hydrogen Peroxide Signaling through Tumor Necrosis Factor Receptor 1 Leads to Selective Activation of c-Jun N-terminal Kinase J. Biol. Chem., November 7, 2003; 278(45): 44091 - 44096. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Waris, A. Livolsi, V. Imbert, J.-F. Peyron, and A. Siddiqui Hepatitis C Virus NS5A and Subgenomic Replicon Activate NF-{kappa}B via Tyrosine Phosphorylation of I{kappa}B{alpha} and Its Degradation by Calpain Protease J. Biol. Chem., October 17, 2003; 278(42): 40778 - 40787. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Gielen, V. Adams, S. Mobius-Winkler, A. Linke, S. Erbs, J. Yu, W. Kempf, A. Schubert, G. Schuler, and R. Hambrecht Anti-inflammatory effects of exercise training in the skeletal muscle of patients with chronic heart failure J. Am. Coll. Cardiol., September 3, 2003; 42(5): 861 - 868. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Linard, A. Ropenga, M. C. Vozenin-Brotons, A. Chapel, and D. Mathe Abdominal irradiation increases inflammatory cytokine expression and activates NF-{kappa}B in rat ileal muscularis layer Am J Physiol Gastrointest Liver Physiol, August 8, 2003; 285(3): G556 - G565. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Ma, K. Kinneer, J. Ye, and B. J. Chen Inhibition of Nuclear Factor {kappa}B by Phenolic Antioxidants: Interplay between Antioxidant Signaling and Inflammatory Cytokine Expression Mol. Pharmacol., August 1, 2003; 64(2): 211 - 219. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Madebo, B. Lindtjorn, P. Aukrust, and R. K Berge Circulating antioxidants and lipid peroxidation products in untreated tuberculosis patients in Ethiopia Am. J. Clinical Nutrition, July 1, 2003; 78(1): 117 - 122. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. M. Fries, E. Paxinou, M. Themistocleous, E. Swanberg, K. K. Griendling, D. Salvemini, J. W. Slot, H. F. G. Heijnen, S. L. Hazen, and H. Ischiropoulos Expression of Inducible Nitric-oxide Synthase and Intracellular Protein Tyrosine Nitration in Vascular Smooth Muscle Cells: ROLE OF REACTIVE OXYGEN SPECIES J. Biol. Chem., June 13, 2003; 278(25): 22901 - 22907. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. P. Rodrigues, S. Sola, Z. Nan, R. E. Castro, P. S. Ribeiro, W. C. Low, and C. J. Steer Tauroursodeoxycholic acid reduces apoptosis and protects against neurological injury after acute hemorrhagic stroke in rats PNAS, May 13, 2003; 100(10): 6087 - 6092. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Fiuza, M. Bustin, S. Talwar, M. Tropea, E. Gerstenberger, J. H. Shelhamer, and A. F. Suffredini Inflammation-promoting activity of HMGB1 on human microvascular endothelial cells Blood, April 1, 2003; 101(7): 2652 - 2660. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Risnes, T. Ueland, R. Lundblad, T. E. Mollnes, S. T. Baksaas, P. Aukrust, and J. L. Svennevig Changes in the cytokine network and complement parameters during open heart surgery Interactive CardioVascular and Thoracic Surgery, March 1, 2003; 2(1): 19 - 24. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. H. Boulares, A. J. Zoltoski, Z. A. Sherif, P. Jolly, D. Massaro, and M. E. Smulson Gene Knockout or Pharmacological Inhibition of Poly(ADP-Ribose) Polymerase-1 Prevents Lung Inflammation in a Murine Model of Asthma Am. J. Respir. Cell Mol. Biol., March 1, 2003; 28(3): 322 - 329. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Schafer, T. Cramer, G. Suske, W. Kemmner, B. Wiedenmann, and M. Hocker Oxidative Stress Regulates Vascular Endothelial Growth Factor-A Gene Transcription through Sp1- and Sp3-dependent Activation of Two Proximal GC-rich Promoter Elements J. Biol. Chem., February 28, 2003; 278(10): 8190 - 8198. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. D. Wheeler and R. G. Thurman Up-regulation of CD14 in Liver Caused by Acute Ethanol Involves Oxidant-dependent AP-1 Pathway J. Biol. Chem., February 28, 2003; 278(10): 8435 - 8441. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Macdonald, H. F. Galley, and N. R. Webster Oxidative stress and gene expression in sepsis Br. J. Anaesth., February 1, 2003; 90(2): 221 - 232. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Shibukawa, M. Takahashi, I. Laffont, K. Honke, and N. Taniguchi Down-regulation of Hydrogen Peroxide-induced PKCdelta Activation in N-Acetylglucosaminyltransferase III-transfected HeLaS3 Cells J. Biol. Chem., January 24, 2003; 278(5): 3197 - 3203. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. M. W. Janssen-Heininger, R. L. Persinger, S. H. Korn, C. Pantano, B. McElhinney, N. L. Reynaert, R. C. J. Langen, K. Ckless, P. Shrivastava, and M. E. Poynter Reactive Nitrogen Species and Cell Signaling: Implications for Death or Survival of Lung Epithelium Am. J. Respir. Crit. Care Med., December 15, 2002; 166(12): S9 - 16. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. I. Azzam, S. M. de Toledo, D. R. Spitz, and J. B. Little Oxidative Metabolism Modulates Signal Transduction and Micronucleus Formation in Bystander Cells from {alpha}-Particle-irradiated Normal Human Fibroblast Cultures Cancer Res., October 1, 2002; 62(19): 5436 - 5442. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. G. Calfee-Mason, B. T. Spear, and H. P. Glauert Vitamin E Inhibits Hepatic NF-{kappa}B Activation in Rats Administered the Hepatic Tumor Promoter, Phenobarbital J. Nutr., October 1, 2002; 132(10): 3178 - 3185. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
