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The FASEB Journal, Vol 10, 587-597, Copyright © 1996 by The Federation of American Societies for Experimental Biology

REVIEWS

The role of proteases during apoptosis

T Patel, GJ Gores and SH Kaufmann
Center for Basic Research in Digestive Diseases, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA.

The importance of proteases during apoptosis is becoming increasingly apparent. Because apoptosis contributes to a diverse variety of disease processes, understanding the roles played by proteases and their inhibitors might provide insight into the pathogenesis of these conditions and suggest novel therapeutic strategies. In this review, we discuss the involvement and role of specific proteases, substrates, and protease inhibitors that appear to participate in the apoptotic process.


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