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(The FASEB Journal. 2008;22:lb707)
© 2008 FASEB
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lb707

Quercetin suppresses the hyperlipidemia induced by an atherogenic diet in mice

JAEHO PARK, JIYUN AHN, SUNA KIM and TAE YOUL HA

KFRI, SUNGNAM-SI, Korea, Republic of

ABSTRACT

Quercetin is a phenolic antioxidant enriched in onions, red wine, and green tea. Anti-obesity effects of the quercetin remain unclear, although the quercetin has been considered to play roles in human diseases. Therefore, we have investigated the effects of the quercetin on the obese mice induced by an atherogenic diet. The significant decreases in the body weight and the visceral fat accumulation in the mice fed with the quercetin (250 mg/kg). The cholesterol and triglyceride levels were significantly reduced in the quecetin treated group. The concentration of Apo A-I in the serum was significantly increased to the normal level while Apo B level was decreased in the quercetin treated group. Histological analyses revealed the accumulations of lipid and/or triglyceride in hepatic tissue and the hyperlipidemia in adipose tissues in the diet-induced obese mice. Of important, the quercetin reduced the accumulations of lipid and triglyceride, which is consistent with the analysis of the serum and attenuated the hyperlipidemia in these tissues. Taken together, these results demonstrate that the quercetin can prevent the atherogenic diet-induced hyperlipidemia in mice.





This Article
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