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(The FASEB Journal. 2008;22:lb44)
© 2008 FASEB
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lb44

Intermittent fasting: fly in the oatmeal

Mark I Talan1, Ismayil Ahmet1, Ruiqian Wan2, Mark P Mattson2 and Edward G Lakatta1

1 Laboratory of Cardiovascular Sciences
2 Laboratory of Neuroscience, National Institute on Aging, Baltimore, MD

ABSTRACT

Intermittent fasting (IF), a dietary regimen of periodical fast (for example, every other day), results in weight loss and may have multiple health benefits. In rodents IF increases the life span and reduces the incidence of age-associated diseases. We have reported strong neuroprotective and cardioprotective effects of IF against ischemic injury. The objective of this study was to assess the effect of long term IF on cardiac structure and function. Two groups of 4 mo old male SD rats were subjected to either IF or a regular diet for 3 months and then cardiac function was evaluated by echocardiogtrapy followed be pressure-volume (P-V) loop analyses under normal conditions and under stress induced by inotropic stimulation and volume load. Echocardiography showed a relative LV enlargement with a small reduction of ejection fraction and substantial increase of left atrial size in IF rats. P-V loop analyses revealed indices of diastolic dysfunction. During the stress test the Preload Recruitable Stroke Work and the ratio of End-diastolic volume to End-diastolic pressure were lower in IF than in control rats, unmasking a diminishing cardiac reserve and reduced diastolic capacity in IF. The present data suggest that effects of IF on the cardiovascular system are not entirely beneficial.

The work was supported by Intramural Research Program of NIA.





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