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lb238 |
1 Biochemistry
2 Internal Medicine (Endocrine Unit), Ain Shams University, Cairo, Egypt
3 Biochemistry, Fayoum University, Fayoum, Egypt
ABSTRACT
Bachground: Essential hypertension is a leading cause of stroke, cardiovascular disease, and a major health problem in the world. MTHFR catalyzes the interconversion of 5, 10-Methylene tetrahydrofolate (MTHF) into 5-methyltetrahydrofolate, which serve as a carbon donor in the remethylation of homocysteine to methionine.
Aim: To study the association of MTHFR polymorphism C677T and hypertension.
Methods: MTHFR C677T genotypes were determined by Polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) assay in 132 patients with hypertension and 164 normal controls. Analysis of data was done by IBM computer using SPSS program.
Results: The frequency of the MTHFR-mutated allele (T) was 39.4% in the hypertension group versus 21.9% in the controls. The homozygous mutation (T/T) in MTHFR gene was identified in 21.2% of hypertension group versus 14.6% of the controls. Patients with the (TT) and (CT) genotype showed a higher prevalence of hypertension when compared with CC genotype (Odds Ratio (OR)=3.3 and 95% confidence interval (CI)= 2.0- 5.3).
Conclusion:The MTHFR C677T mutant gene may be a possible risk factor for the development of hypertension.
Source of research support: Ain Shams University, Cairo, Egypt.
Key Words: Hypertension • Methylene tetrahydrofolate reductase • genetic polymorphism
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