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lb237 |
1 Biochemistry
2 Internal Medicine (Endocrine Unit), Ain Shams University, Cairo, Egypt
3 Biochemistry, Fayoum University, Fayoum, Egypt
ABSTRACT
Backgroung: Lipoprotein lipase (LPL) enzyme plays a central role in lipid metabolism. The primary function of LPL enzyme is the hydrolysis of the core triglycerides of circulating chylomicron and very low density lipoprotein. It releases monoglycerides and free fatty acids, which are taken up by skeletal muscle or adipose tissue.
Aim: To study the association of the common variant of LPL HindIII (H+) and hypertension.
Methods: Hind III (+) variant allele of LPL were determined by PCR-restriction fragment length polymorphism (RFLP) assay in 150 hypertensive patients and 150 normotensive as a control group. Serum lipoproteins were also observed in both groups.
Results: Allele frequencies were H+= 0.733 and H– =0.267 for LPL HindIII in the hypertension group compared to H+= 0.683 and H– = 0.317 in the control group. Individuals with homozygous (H+/+) genotype were at higher risk of developing hypertension compared to the (H–/–) genotype (Odds Ratio OR= 2.13, CI= 0.94–4.8). Serum TG level were also higher in the individuals with (H+/+) genotype compared to the (H–/–) genotype, while high density lipoprotein showed negative correlation with the presence of (H+/+) genotype.
Conclusion: The LPL HindIII (H+) variant of LPL may influence the blood lipid metabolism and increase risk for hypertension.
Source of research support: Ain Shams University, Egypt.
Key Words: LPL HindIII polymorphism • Hypertension • Triglycerides • HDL
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