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(The FASEB Journal. 2008;22:lb151)
© 2008 FASEB
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lb151

Circadian heart rate variability is abolished by chronic administration of lisinopril in spontaneously hypertensive rats

Sulayma Albarwani1, Sultan Al-Siyabi1, Hajar Ba-Omar1 and Musbah O Tanira2

1 Physiology
2 Pharmacology and Clinical Pharmacy, Sultan Qaboos University, Muscat, Oman

ABSTRACT

The circadian variation of cardiac autonomic modulation is well established. In cardiovascular disease, autonomic regulation of heart rate variability (HRV) is widely used to predict the prognosis. We investigated the effect of chronic administration of lisinopril (20mg/Kg/day, 12 weeks) on the circadian HRV profile in spontaneously hypertensive rats. Frequency-domain analysis of the RR-intervals was performed on a weekly average of measurements obtained from 30 minutes beat-beat recordings during night time (awake) and day time (sleep). In control animals (n=5), low frequency (LF) and high frequency (HF) components of HRV were found to be significantly higher during day compared to night (LF: 0.66±0.0013 vs 0.61±0.12; HF: 0.47±0.002 vs 0.4±0.001 sec2/Hz, respectively). Lisinopril treatment (n=6) was associated with higher heart rate (day: 319 ± 6 vs 291± 5; night: 360±13 vs 342±2 bpm) and increased LF and HF tones during day (0.76±0.002, 0.52±0.003 sec2/Hz, respectively) compared to night (0.73±0.01, 0.53±0.03 sec2/Hz, respectively). However, lisnopril eliminated HRV circadian variation. In summary, lisinopril treatment improved HRV indices related to sympathetic and parasympathetic tones and abolished HRV circadian differences.





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