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(The FASEB Journal. 2008;22:lb149)
© 2008 FASEB
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lb149

Effect of chronic lisinopril administration on heart rate variability in spontaneously hypertensive rats

Sultan S Al-Siyabi, Hajar Ba-Omar, Greeshma Mohan and Sulayma A Albarwani

Physiology, Sultan Qaboos University, Muscat, Oman

ABSTRACT

Reduced heart rate variability (HRV) is an independent predictor of cardiac morbidity and mortality in hypertension. Studies examining the effects of angiotensin converting enzyme inhibitors on HRV produced controversial results. We investigated the effect of chronic lisinopril administration on HRV in spontaneously hypertensive rats. Frequency-domain analysis of the RR-intervals was performed to quantify the indices of HRV: low-frequency power (LF, 0.25–1Hz) and high-frequency power (HF, 1–4Hz). Data represents a weekly average of measurements obtained from 30 minutes beat-beat recording during night time (active period). Lisinopril (20 mg/Kg/day) administration for 12 weeks caused significantly lower mean arterial pressure (74 ±5.3 vs 140. ±5.3 mmHg) and higher HR (319 ± 6 vs 291± 5 bpm) compared to the untreated rats. In addition, HRV power spectral density (PSD) of treated rats was increased significantly at LF (0.73±0.1 vs 0.6±0.02 sec2/Hz) and at HF (0.53 ± 0.03 vs ± 0.41±0.002 sec2/Hz) resulting in overall increase in total PSD (2.0±0.001 vs 2.2±0.003 sec2/Hz). Our findings demonstrate that, in addition to the benefit of reducing blood pressure, lisinopril enhanced HRV indices related to sympathetic and vagal tones with minimal changes in sympathovagal tone.





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