| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
449.7 |
1 Canadian Centre for Agri-food Research in Health and Medicine, St. Boniface Hospital Research Centre, Winnipeg, Canada
2 Human Nutritional Sciences, University of Manitoba, Winnipeg, Canada
3 Plant Biotechnology Institute, Saskatoon, 0, Canada
4 Canadian Centre for Agri-food Research in Health and Medicine, St. Boniface Hospital Research Centre, Winnipeg, 0, Canada
ABSTRACT
Background: Diets high in fructose may result in abnormalities in glucose and lipid metabolism.
Purpose: To investigate the effects of a high-fructose diet on liver fatty acid composition.
Methods: Male Sprague-Dawley rats were divided into two groups: a control group (n=5) receiving standard chow diet, and treatment group (n=7) receiving a diet containing 10% w/w lard and 60% w/w fructose for 20 weeks. Fatty acid profile of various lipid fractions in the liver of these animals was characterized.
Results: Total liver lipids including cholesterol and triacyglycerol (TAG) were significantly higher in the treated group as compared to controls. The livers from treated animals had significantly lower levels of C16:0 and higher levels of C18:1 in the TAG fraction, and lower levels of C18:1c11, C18:2c9, C20:1c11, C20:1c13 along with higher levels of C16:1 and C18:1c9 in the free fatty acid fraction. The levels of C16:0, C18:2c9, C20:1c11, C20:1c13, C20:2c11 and C24:0 were significantly increased in the phosholipid fraction of the treated animals.
Conclusions: High intakes of fructose change liver lipid composition and fatty acid profile in rats. TAG and phospholipid fractions seem to be affected more. These changes may lead to alterations in hepatocyte functions including lipid metabolism and may modify cardiovascular risk.
| ||||||||||||||||||||||||||||||||||||||||||||
