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(The FASEB Journal. 2008;22:1129.6)
© 2008 FASEB
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(The FASEB Journal. 2008;22:1129.6.)
© 2008 FASEB

1129.6

Ethanol feeding enhances the hypotensive action of enalapril in telemetered female rats: Role of bradykinin B2 receptors

Mahmoud M El-Mas and Abdel A Abdel-Rahman

Pharmacology, School of Medicine, East Carolina Univ, Greenville, NC

ABSTRACT

We investigsated the effect of chronic ethanol feeding on acute hemodynamic actions of enalapril in telemetered female rats and the role of bradykinin B2 receptors in the interaction. Changes evoked by enalapril (10 mg/kg i.p.) in blood pressure (BP), heart rate (HR), myocardial contractility (dP/dtmax), and power spectral indices of hemodynamic variability were evaluated in female rats receiving liquid diet with or without ethanol (5%, w/v, 8 weeks). Ethanol feeding reduced BP and dP/dtmax versus no effect on HR or hemodynamic variability. Enalapril decreased BP in control rats for at least 5 hrs and increased the low-frequency (LF, 0.25–0.75 Hz), but not high-frequency (HF, 0.75–3 Hz), spectral power of interbeat intervals (IBI) and IBILF/HF ratio, suggesting cardiac sympathetic dominance. In ethanol-fed rats, enalapril elicited significantly greater hypotension and abolished the increase in cardiac sympathetic activity. Blockade of bradykinin B2 receptors by bradyzide (2 mg/kg i.p.) abolished the augmented hypotensive effect of enalapril in ethanol-fed rats. In control rats, bradyzide eliminated the increase in cardiac sympathetic activity but had no effect on enalapril hypotension. These findings suggest that chronic ethanol enhances enalapril-evoked hypotension in female rats, at least partly, via facilitation of bradykinin B2 receptor signaling.

Supported by Grant R01 AA014441 from NIAAA.





This Article
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Right arrow Articles by El-Mas, M. M
Right arrow Articles by Abdel-Rahman, A. A
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Right arrow Articles by El-Mas, M. M
Right arrow Articles by Abdel-Rahman, A. A