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(The FASEB Journal. 2007;21:968.10)
© 2007 FASEB
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968.10

pH sensitivity of carotid body glomus cells is augmented in spontaneously hypertensive rats

Zhiyong Tan1, Carol A. Whiteis1, Mark W. Chapleau1,2 and Francois M. Abboud1

1 Internal Medicine, University of Iowa, 200 Hawkins Dr., Iowa City, IA, 52242,
2 Vet Aff Med Ctr, Hwy 6W, Iowa City, IA, 52246

ABSTRACT

Glomus cells in carotid body are peripheral arterial chemoreceptors activated by hypoxia, hypercapnia and low pH. Chemoreceptor sensitivity to hypoxia is enhanced in several pathological states including hypertension (1). We hypothesized that chemoreceptor sensitivity to decrease in pH is augmented in spontaneously hypertensive rats (SHR). Whole-cell patch clamping was used to assess the pH sensitivity of glomus cells isolated from carotid bodies of five Sprague Dawley (SD) rats and five SHR at a young age of 4–6 weeks. At resting membrane potential (RMP), glomus cells (11 SD and 8 SHR) were perfused with acidic bath solutions with different pH levels. The RMP of glomus cells was more negative (–40.6±3.0 mV) in SHR than in SD rats (–28.0±2.9 mV) (P<0.05). Decreases in extracellular pH from 7.4 to 7.0, 6.5, 6.0 depolarized SHR glomus cells to a greater extent (13±1, 24±2, 33±3 mV) than SD glomus cells (7±1, 14±1, 20±1 mV) (P<0.05). We conclude that carotid body chemoreceptors in young SHR are hypersensitive to decreases in pH compared with chemoreceptors in age-matched SD rats. This enhanced pH sensitivity of glomus cells may contribute to increased chemoreception drive and excessive sympathetic nerve activity in hypertension. [HL 14388]

REFERENCES

  1. Trzebski A. Arterial chemoreceptor reflex and hypertension. Hypertension. 1992 Jun;19(6 Pt 1):562–6.




This Article
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