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838.4 |
1 College of Pharmacy & Nutrition, University of Saskatchewan, 110 Science Place, Saskatoon, S7N 5C9, Canada,
2 WCVM, University of Saskatchewan, 52 Campus Drive, Saskatoon, S7N 5B4, Canada
ABSTRACT
Acidosis despite its origin is treated by quick correction of blood pH via bicarbonate infusion (NaHCO3). However, NaHCO3 treatment can worsen the acidotic condition in the cerebral spinal fluid (CSF). The objective was to determine the effect of rapid versus slow NaHCO3 rates on paradoxical CSF acidosis in experimentally induced acidosis via DL-lactic acid (DL-LA) or hydrochloric acid (HCl). Nine calves (63±4kg, 27±5d) with atlanto-occipital CSF, ear arterial and jugular venous catheters were infused with DL-LA or HCl until severely acidotic (>12h). Acidotic calves were then treated with NaHCO3 for 4h (rapid) or 24h (slow). Blood and CSF were collected at pre, post acidotic and during NaHCO3 therapy, and assessed for acidotic state. Calves were also evaluated for neurological disturbances (ND). HCl and DL-LA induced acidosis responded to NaHCO3 (rapid & slow) with 54% pH recovery at 8h of treatment; however, paradoxical CSF was apparent during the first 4h in 3 groups (pH 7.23±0.09 or >15% drop at 2h) but not for DL-LA (rapid). NaHCO3 (rapid) increased CSF pCO2 to 46±2 mmHg (p<0.05) with >75% recovery by 4h. NaHCO3 was also effective in correcting CSF HCO3– (45%) in all except HCl (slow) group (10%) by 8h. Severe ND were present in DL-LA induced acidosis, but not HCl (p<0.05), and these ND persisted during NaHCO3 therapies. Overall NaHCO3 regimens were clinically safe; however, they did not relieve ND caused by DL-LA. Other treatments especially targeting the origin of acidosis need investigation.
(Supported by NSERC Canada)
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