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(The FASEB Journal. 2006;20:A829)
© 2006 FASEB
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494.2

Korean pine nut fatty acids affect appetite sensations, plasma CCK and GLP1 in overweight subjects

Alexandra Wilhelmina Einerhand1, Wilrike Pasman2, Carina Rubingh2, Rene van den Berg2, Marianne O’Shea1, Luisa Gambelli1 and Henk Hendriks2

1 Loders Croklaan, Lipid Nutrition, PO box 4, Wormerveer, 1520 AA, Netherlands,
2 Quality of Life, TNO, P.O. Box 360, Zeist, 3700 AJ, Netherlands

ABSTRACT

Cholecystokinin (CCK) is one of the best studied appetite suppressing hormones. Previous experiments showed that polyunsaturated fatty acids (PUFAs) derived from Korean pine nuts (Pinus Koraiensis) induced high amounts of CCK release by STC-1 enteroendocrine cells in comparison to other PUFAs and MUFAs. This study investigates the effect of Korean pine nut PUFAs on appetite sensations and appetite-regulating hormones in humans. A randomized, cross-over, placebo-controlled double-blind study was carried out with 18 overweight women (BMI=25–30 kg/m2) receiving capsules with 3 g PUFAs derived from Korean pine nuts (PinnoThinTM) or olive oil (placebo) in combination with a light breakfast consisting of two slices of white bread and marmalade. At 0, 30, 60, 90, 120, 180 and 240 min following supplementation blood samples were taken for analyses of CCK and GLP1 and appetite sensations were evaluated by using visual analogue scales. Korean pine nut PUFAs significantly induced CCK after 30 min and GLP1 after 60 min relative to placebo. Over a period of 4 hours the total amount of plasma CCK and GLP1 in response to pine nut PUFAs was 60% (P<0.0001) and 25% (P<0.05) higher than in response to placebo, respectively. Korean pine nut PUFAs affected appetite sensations during the 4 hours after intake. Especially, at 30 minutes the "desire to eat" and the "prospective food intake" scores were, 29% and 36% lower relative to placebo, respectively. Similar results were obtained with Korean pine nut triglycerides. In conclusion: Korean pine nut PUFAs induced CCK and GLP1 levels significantly for up to 4 hours and also appetite sensations were affected, indicating that Korean pine nut PUFAs suppress appetite and affect food intake.





This Article
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Right arrow Articles by Einerhand, A. W.
Right arrow Articles by Hendriks, H.
PubMed
Right arrow Articles by Einerhand, A. W.
Right arrow Articles by Hendriks, H.