Prevention and restoration of lactacystin-induced nigrostriatal dopamine neuron degeneration by novel brain-permeable iron chelators FASEB J. Zhu et al.
21: 3835
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Supplemental Figure 1
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( 07-8386SuppFigure.tif; 3.81 MB)
Lactacystin induced protein aggregation in DA neurons. The effect of lactacystin on inducing protein aggregation was examined on day 28 by immunofluorescent staining. Both α-synuclein-positive and ubiquitin-positive protein aggregations were seen in the DA neurons. a) Representative photomicrographs of immunofluorescence of TH and α-synuclein. b) Representative photomicrographs of immunofluorescence of TH and α-synuclein. α-syn stands for α-synuclein immunofluorescence; Ubi stands for ubiquitin immunofluorescence.
