Supplemental Data

Files in this Data Supplement:

• Supplemental Figure 1 - (07-8218SupplementalFigure1.pdf; 50 KB) Correlation of loading protocol to the phases of wound healing. a) Wounds were created on day 0. Loading was initiated during the proliferative phase of wound healing (days 4–10). Load was re-applied every other day for up to two weeks. Scar tissue was harvested at 0, 1, 2, 3, 4, 6, 10, and 24 weeks following initiation of load.
• Supplemental Figure 2 - (07-8218SupplementalFigure2.pdf; 4.09 MB) Initiation of hypertrophic scarring is independent of the vector of applied load a) To be certain that wound dehiscence was not occurring, the vector of applied load was changed so that it was parallel to the incision. b) This protocol also resulted in significantly increased fibrosis and hyperplasia (P<01).