Bcl-2 overexpression delays caspase-3 activation and rescues cerebellar degeneration in prion-deficient mice that overexpress amino-terminally truncated prion FASEB J. Nicolas et al.
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Supplemental Data
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Supplemental Figure 1
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(SuppFIG 1.jpg; 251 KB) A–B) Low (A) and high (B) power views of cerebellar cytoarchitecture in longitudinal sections of ΔPrP Bcl-2 (score +) mice at 110 days. Note the mild cerebellar degeneration and the reduction of GC in anterior lobes. Note in B the emerging disorganization of the PC layer (arrows) and the vacuolization in the white matter of the vermis region.
