Supplemental Data

Files in this Data Supplement:

• Supplemental Data - (SupplementalData.pdf; 3.47 MB)
  Figure S1: Analysis of the binding of PNA2582.
  Figure S2: Zorro LNA/plasmid binding kinetics Zorro LNA was hybridized with plasmid PN252BS at the ratio of 10:1 (blue dots) or 1:1 (red dots) at 37°C for different time periods (0, 5, 15 minutes and 1, 3, 5, 8, 12, 16 and 30 hours).
  Figure S3: DNA duplex binding efficiency of Zorro LNA under physiological conditions.
  Figure S4: Exploration of mechanism of inhibition induced by Zorro LNA.
  Figure S5: Electroporation of plasmid PN252BS, pre-hybridized with bisPNA or Zorro LNA, into cells.
  Figure S6: Effect of PNA on inhibition of d2EGFP expression in UV4 cells.
  Figure S7: Effect of LNA7472 on inhibition of d2EGFP expression.