Supplemental Data

Files in this Data Supplement:

• Supplemental Table 1 - Echocardiographic parameters after AMI (SupplementalTable1.pdf; 20 KB)
• Supplemental Figure 1 - Histological analysis and cardiac gene expression after MI SupplementalFigure1.pdf; 88 KB)
  To study the role of MAPKs in post-infarction remodeling, the LAD was ligated in male Sprague-Dawley rats. To validate the experimental protocol, histological analysis was performed in various time points. The mRNA levels of ANP and BNP were measured by northern blotting at the same time points. A, Representative hematoxylin-eosin stained myocardial sections describing the progressive anterior wall thinning, posterior wall hypertrophy and LV dilatation in the hearts subjected to MI are shown. B) Northern blot analysis of ANP and BNP mRNA levels. Results are mean±SEM (n=6–8). *P<0.05 vs. sham-operated rats, **P<0.01 vs. sham-operated rats (Student’s t test). AMI indicates acute myocardial infarction.