HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Swijnenburg, R.-J. Articles by Robbins, R. C. Search for Related Content PubMed PubMed Citation Articles by Swijnenburg, R.-J. Articles by Robbins, R. C. Related Collections Related Articles

Comment on "Transplantation of undifferentiated murine embryonic stem cells in the heart: teratoma formation and immune response"

Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California, USA

¹Correspondence: robbins{at}stanford.edu

The recently published manuscript by Nussbaum et al. (1) describes teratoma formation and the generation of a host immune response following transplantation of undifferentiated murine embryonic stem cells into the heart. These are important findings, emphasizing the hurdles that need to be overcome before embryonic stem cell therapy can become a clinical reality. We thought it proper to remind the readership of The FASEB Journal of our study detailing undifferentiated embryonic stem cell transplantation into the heart published in 2005 (2) . In this study, we presented evidence that undifferentiated embryonic stem cells transplanted into the heart both form teratomas and elicit an immune response by the host. We specifically classified the immune response by examining cellular infiltrates into the heart and presented proof of teratoma formation in both syngeneic and allogeneic recipients.

We were somewhat surprised, then, that Dr. Nussbaum’s manuscript does not refer to this previously published work while presenting similar conclusions to those put forth by our study.

FOOTNOTES

The opinions expressed in editorials, essays, letters to the editor, and articles comprising the Up Front section are those of the authors and do not necessarily reflect the opinions of FASEB or its constituent societies. The FASEB Journal welcomes all points of view and many voices. We look forward to hearing these in the form of op-ed pieces and/or letters from its readers addressed to journals@faseb.org.

REFERENCES

1. Nussbaum, J., Minami, E., Laflamme, M. A., Virag, J. A., Ware, C. B., Masino, A., Muskheli, V., Pabon, L., Reinecke, H., Murry, C. E. (2007) Transplantation of undifferentiated murine embryonic stem cells in the heart: teratoma formation and immune response. Faseb J. Published online before print February 6, 2007 as doi: 10.1096/fj.06-6769com
2. Swijnenburg, R. J., Tanaka, M., Vogel, H., Baker, J., Kofidis, T., Gunawan, F., Lebl, D. R., Caffarelli, A. D., de Bruin, J. L., Fedoseyeva, E. V., Robbins, R. C. (2005) Embryonic stem cell immunogenicity increases upon differentiation after transplantation into ischemic myocardium. Circulation 112,I166-I172

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Swijnenburg, R.-J. Articles by Robbins, R. C. Search for Related Content PubMed PubMed Citation Articles by Swijnenburg, R.-J. Articles by Robbins, R. C. Related Collections Related Articles