FASEB J.
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Figure 1


Figure 1. CD109 forms a heteromeric complex with the TGF-ß signaling receptors. HaCaT cells were affinity-labeled with [125I]TGF-ß1 and membrane extracts were left not-immunoprecipitated (NIP, lane 1) or immunoprecipitated (IP) with anti-CD109 (1B3, lane 2) or anti-type I ({alpha}RI, lane 3) antibodies or IgG (control, lane 4). 1B3 immunoprecipitates r150/CD109 and coimmunoprecipitates detectable amounts of type I and II receptors (RI and RII), while {alpha}RI immunoprecipitates RI and co-immunoprecipitates RII and detectable amounts of r150/CD109. IgG failed to immunprecipitate any [125I]TGF-ß1-associated proteins.





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