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Figure 2. GIPC involves angiogenesis. A) Expression of GIPC in zebrafish. Upper rank reveals the whole mount in situ hybridization of zGIPC in different stages of zebrafish embryos. Dorsal is up and anterior is left. Lower rank shows transverse section through the trunk of different stages of zebrafish embryos. Dorsal is up. Arrowheads depict zGIPC-expressing cells. B) GIPC is required for DLAV and SIV formation during zebrafish angiogenesis. Confocal images of 2 days postfertilization TG(fli1:egfp) embryos. Upper three ranks reveal phenotypes of morpholinos. Lower panel) Percentage of vessel defects (n=120 and 65 at 1.25 ng and 10 ng GIPC morpholion injection groups, respectively).
