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Figure 1. Airway epithelial-specific targeting in novel CCtCre line. Functional recombination activity in mice expressing Cre recombinase under control of the 2.4 kb Rat CC10 promoter was assessed using the ROSA26 Cre reporter mouse. All newborn (A and B) and mature (C and D) animals containing a copy of both transgenes showed staining within the lung. A and C) Whole mount of lungs reveal staining in the characteristic branching pattern of the airway. B and D) Histological sections show that staining is restricted to epithelial cells within the conducting airway. Further, only a minority of airway epithelial cells is stained in newborn lungs (B) while a majority of cells is stained in mature lungs (D).
