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Figure 3. Schematic model of molecular mechanisms by which IL-10 inhibits priming of ROS production induced by GM-CSF in PMN. GM-CSF induces partial phosphorylation of p47PHOX via activation of ERK1/2, and this results in priming of ROS production. When present, IL-10 inhibits ERK1/2 activity at a postphosphorylation step, and this inhibition leads to a decrease in GM-CSF-induced p47PHOX phosphorylation; as a result, GM-CSF-induced priming of ROS production is inhibited.
