Click on image to view larger version.
Figure 3. Summary diagram: Rafts and caveolae as a proximal relay point for prosurvival signaling in response to ROS. On exposure to exogenous H2O2, Akt localized within cholesterol- and sphingolipid lipid-rich plasma membrane microdomains (rafts/caveolae) becomes activated and functions as a crucial prosurvival signaling factor that inactivates apoptotic caspase molecules. The activation of ERK1/2 also confers protection from detrimental effects of ROS through a mechanism that relies on rafts/caveolae and potentially through transactivation of lipid raft localized epidermal growth factor receptor (EGFr).
