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Figure 3. Schematic diagram depicting the regulation of cell-matrix adhesion dynamics and cell spreading as determined by expressing a constitutively membrane-anchored form of ILK (ILK-GFP-F) or ILK silencing by RNA interference. ILK-GFP-F is retained in integrin-based adhesive structures, where it enhances their formation and stability. The ILK/PKL/ßPIX complex participates in Rac-1 regulation by ILK. Regulation of cell spreading by ILK proceeds through Rac-dependent and Rac-independent mechanisms.
