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Figure 2. CaMK inhibition increases H2O2-induced apoptosis. S-phase synchronized HUVEC were treated with CaMK inhibitor KN93 (10 µmol/l) or solvent alone followed by incubation with or without 400 µmol/l H2O2 for additional 24 h. Apoptosis was measured by calculating percentage of cells displaying subdiploid DNA content (left, n=11) or the apoptotic DNA fragmentation (right, n=4). In cells incubated with KN93 and H2O2, apoptosis significantly increased over both cells treated with H2O2 alone or KN93 alone.
