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Figure 3. Schematic diagram. Proposed mechanism for PPAR
agonist-induced edema and weight gain through protein kinase C (PKC)-mediated increase in vascular permeability of adipose tissue. DAG, diacylglycerol; PKC, protein kinase C; VEGF, vascular endothelial growth factor; ruboxistaurin, PKCß isoform selective inhibitor.
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