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Figure 1. In vivo AdV-INH-2 gene transfer improves LV systolic function in cardiomyopathic (CM) hamsters. A) The left ventricular (LV) end-diastolic dimension (LVDd) and percent fractional shortening (%FS) at 14 wk of age are shown for normal (N) and CM hamsters (n=10 in each group). #P < 0.05 compared with normal hamsters. B) Representative Bluo-gal staining is shown at 7 days after AdV-LacZ gene transfer in a CM hamster. High magnification of the rectangular area is shown (bottom). C) The LV end-diastolic and systolic dimensions (LVDd, LVDs) are shown for CM hamsters at 7 days after the gene transfer (GT) of LacZ (open circles, n=8) or INH-2 (solid squares, n=8). The index of wall stress, LVDd/PWT and the changes of %FS are shown for the gene transfer of LacZ (open circles) and INH-2 (solid squares). *P < 0.05 compared with LacZ-treated hamsters. $P < 0.05 compared with pre gene transfer.
