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Figure 3. Schematic overview of the set of methods used to isolate and sequence the active principle from Ximenia americana plant material (upper region) as well as of the in vitro and in vivo effects of the isolated proteins (lower region). The molecular model of the new type II RIP, termed riproximin, is depicted in the center of the drawing and shows the catalytic site of the A chain (red), the intermolecular disulfide bridge (yellow), the B chain sugar binding domains 1
(green) and 2
(pink) as well as the potential N-glycosylation sites (dark blue).
