FASEB J.
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Figure 3


Figure 3. Schematic diagram. Proposed model of the influence of HSP27 on ubiquitination and proteasomal degradation of p27Kip1. In response to a stress, p27Kip1 translocates from the nucleus to the cytosol. HSP27 interacts with p27Kip1 and favors its ubiquitination and degradation. This effect favors the progression from the G0-/G1-phase to the S-phase of the cell cycle.





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