FASEB J.
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Figure 1


Figure 1. Asbestos inhalation causes increases in steady-state mRNA levels of lung MMP12, MMP13, and TIMP1 in WT mice [PKC{delta}(+/+)]; MMP12 and MMP13 are inhibited in PKC{delta} (–/–) mice. WT and PKC{delta} (–/–) mice were exposed to asbestos (7 mg/m3, 6 h/day, 5 d/week for 3, 9, or 40 d). RNA was prepared from the lung, purified, and subjected to microarray analysis using an U74Av2 oligonucleotide chip. Data were analyzed using the GeneSifter program and validated by ribonuclease protection assays (RPAs). A) Time-dependent effects of asbestos inhalation on MMP12. B) Effect of asbestos inhalation (3 d) on MMP12 levels in PKC{delta} (–/–) mice. C) Effect of asbestos inhalation (9 d) on MMP13 levels in WT and PKC{delta} (–/–) mice.*P ≤ 0.05 compared with respective control group, #P ≤ 0.05 as compared with asbestos exposed group.





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