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Figure 2. NAADP activates TRPM2 in HEK-293 and Jurkat T cells. A) Average membrane currents recorded at –80 mV induced by perfusion of TRPM2-expressing HEK-293 cells with various concentrations of NAADP ranging from 30 µM to 3 mM (n=4–7). B) Representative current-voltage relationship derived from currents evoked by voltage ramps spanning –100 to + 100 mV. C) Average membrane currents recorded at –80 and + 80 mV induced by perfusion of Jurkat T cells with 1 mM NAADP (n=5).
