Click on image to view larger version.
Figure 1. Native TRPM2 currents in Jurkat T cells. A) Average membrane currents recorded at –80 mV induced by perfusion of Jurkat cells with various concentrations of ADPR ranging from 3 µM to 1 mM (n=5–8) (B) Average membrane currents recorded at –80 mV induced with various concentrations of cADPR ranging from 30 µM to 1 mM (n=4–5). C) Representative current-voltage relationships derived from currents evoked by voltage ramps spanning –100 to + 100 mV. D) Dose-response relationships for IADPR in Jurkat cells evoked by ADPR (filled symbols) or cADPR (open symbols).
