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Figure 3. Schematic diagram depicting the possible mechanism involved in cannabinoid-induced inhibition of melanoma cell proliferation. Activation of cannabinoid receptors on melanoma cells inhibits Akt, which decreases pRb retinoblastoma protein phosphorylation, leading, in turn, to cell cycle arrest at the G1-S transition and decreased cell proliferation. It cannot be ruled out that additional pathways contribute as well to cannabinoid antitumoral action in melanoma cells.
