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Figure 3. hCG plays a key role in the angiogenic synchrony between trophoblast, endothelial and EEC.
Schematic diagram depicting the angiogenic activity of hCG during implantation regarding to our findings. 1) Direct angiogenic effect of hCG via interaction with LH/hCG R at the surface of endothelial cells resulting in an increase of proliferation and capillary outgrowth. 2) Indirect angiogenic effect via a paracrine loop involving an enhanced secretion of VEGF by EEC under the control of hCG. 3) Additive effect of hCG and VEGF in stimulating capillary outgrowth.
