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Figure 2. The effect of thiazolidinedione administration on liver regeneration in mice was analyzed. The results showed that these PPAR
-activating drugs have no effect on early TNF
-IL6-STAT3 signaling, augment late cytokine signaling, suppress cyclin expression, and inhibit hepatocellular proliferation during liver regeneration, with efficacies that correlate with their relative PPAR-activating potencies (i.e. rosiglitazone exhibited the greatest inhibitory effect). These studies provide the first evidence linking regulation of PPAR activity and the hepatic regenerative response.
