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Figure 2. Inhibitory effects of paraherquamide and 2-desoxyparaherquamide on G25, G35, and G45 are statistically different. Left) 1 µM paraherquamide had a greater effect on normalized Popen (NPo) mean ± SE of G35 channels (67.7±10.0% inhibition P<0.05, n=5) and G45 channels (68.2±7.0% inhibition P<0.05, n=5 and) than on the G25 channels (106±25.45, n=5); G25, G35, and G45 channels were activated by 30 µM levamisole. Right) 3 µM 2-desoxyparaherquamide had a significantly greater effect on the normalized Popen of 10 µM bephenium-activated G35 channels (36.4±11.4% inhibition, P<0.05, n=4) and G45 channels (73.3±11.4% inhibition, P<0.05, n=5) activated by 10 µM bephenium.
