FASEB J.
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Figure 2


Figure 2. Schematic diagram of factors influencing pulmonary hypertension. Genetic and environmental factors can trigger endothelial cell dysfunction causing an imbalance in key factors that regulate pulmonary vasculature tone. Subsequent pathological events lead to pulmonary hypertension that perpetuates the endothelial dysfunction and further worsens the disease. Gene therapy offers the possibility to intervene into these pathological events.





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