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Figure 2. Plasma TXB2 levels in rats following bolus intravenous (iv) injection of liposomes (80 mg/kg in 0.5 ml). Liposomes were composed of DPPC and 5 mol% of designated conjugates (size range 80–130 nm). Similar results were obtained with liposomes bearing 10–15 mol% DPPE-mPEG350 conjugate or Conj-B (not shown). The 50% serum hemolytic complement activity (CH50) represents values at 8 min post-liposome injection and is expressed as % of respective baseline level. With the exception of Conj-B, CH50 values were significantly different from baseline (2-sided t test, P<0.05).
